Endonasal surgery for pituitary adenomas: surgical technique, intraoperative and postoperative complications
https://doi.org/10.63769/1683-3295-2025-27-3-152-161
Abstract
The review provides basic data concerning the anatomical aspects of surgical treatment of pituitary adenomas with maximum preservation of intact gland tissue. Neurosurgeons mainly use endoscopic transnasal access, which provides a wider field of view, high magnification and angular visualization, which gives it an advantage over microscopic access, which has not been used much lately. Only a detailed knowledge of the anatomy and topographic-anatomical relationships of the structures of this area makes it easy to navigate during surgery and plan less invasive interventions. In addition, data on complications in the postoperative period are presented, which are mainly represented by liquorrhea, water-electrolyte disorders, and information on methods of their prevention is analyzed.
About the Authors
A. N. SkaruboRussian Federation
16 4th Tverskaya-Yamskaya St., Moscow 125047
V. N. Nikolenko
Russian Federation
Bld. 1, 8 Trubetskaya St., Moscow 119991; 1 Leninskiye Gory, Moscow 119991
B. A. Volel
Russian Federation
Bld. 1, 8 Trubetskaya St., Moscow 119991
Yu. O. Zharikov
Russian Federation
Bld. 1, 8 Trubetskaya St., Moscow 119991
A. A. Ivanchenko
Russian Federation
80 Volokolamskoye Shosse, Moscow 125367
T. S. Zharikova
Russian Federation
Tatiana S. Zharikova.
Bld. 1, 8 Trubetskaya St., Moscow 119991; 1 Leninskiye Gory, Moscow 119991
References
1. Pérez-López C., Palpán A.J., Abenza-Abildúa M.J. et al. Non-functioning pituitary adenomas: epidemiology, clinical and postoperative outcome. rev Neurol 2020;71(5):163–70. DOI: 10.33588/rn.7105.2020273
2. AlMalki M.H., Ahmad M.M., Brema I. et al. Contemporary management of clinically non-functioning pituitary adenomas: a clinical review. Clin Med Insights Endocrinol Diabetes 2020;13:1179551420932921. DOI: 10.1177/1179551420932921
3. Kalinin P.L., Kadashev B.A., Fomichev D.V. et al. Surgical treatment for pituitary adenomas. Zhurnal Voprosy neyrokhirurgii im. Burdenko = Burdenko’s Journal of Neurosurgery 2017;81(1):95–107. (In Russ.). DOI: 10.17116/neiro201780795-107
4. Grigoryev A.Yu., Ivashchenko O.V., Nadezhdina E.Yu. The main principles of hemostasis in endoscopic transnasal surgery of chiasmatic mass lesions. Neyrokhirurgiya = Russian Journal of Neurosurgery 2017;4:3–10. (In Russ.).
5. Shkarubo A.N. Atlas of endoscopic endonasal surgery of the base of the skull and craniovertebral articulation. Moscow: ABV-press, 2020. 272 p. (In Russ.).
6. Aleshkina O.Yu., Nikolenko V.N. Basicranial typology of human skull construction. Moscow: Publishing House of the first Sechenov Moscow State Medical university, 2014. 160 p. (In Russ.).
7. Muhammed F.K., Abdullah A.O., Liu Y. Morphology, incidence of bridging, dimensions of sella turcica, and cephalometric standards in three different racial groups. J Craniofac Surg 2019;30(7):2076–81. DOI: 10.1097/SCS.0000000000005964
8. Aleshkina O.Yu., Devyatkin A.A., Bikbaeva T.S. et al. Stereotopic variability of the turkish saddle depending on the type of skull base. Operativnaya khirurgiya i klinicheskaya anatomiya = Russian Journal of Operative Surgery and Clinical Anatomy 2020;4(4):4–8. (In Russ.). DOI: 10.17116/operhirurg202040414
9. Palamar O.I., Huk A.P., Aksyonov R.V. et al. Surgical technique for pituitary adenomas with sphenoid sinus and cavernous sinus. ukrainskiy neyrokhirurgicheskiy zhurnal = ukrainian Neurosurgical Journal 2018;1:73–7. DOI: 10.25305/unj.92095 [In Russian]
10. Zelyova O.V., Zelter P.M., Kolsanov A.V. et al. Anatomical peculiarities of the sphenoidal sinus based on computed tomography data: structural types and correlation with maxillary sinuses. Rossiyskiy mediko-biologicheskiy vestnik = I.P. Pavlov Russian Medical Biological Herald 2021;29(1):13–20. (In Russ.). DOI: 10.23888/PAVLOVJ202129113-20
11. Favier V., Le Corre M., Segnarbieux F. et al. Endoscopic subperichondrial transseptal transsphenoidal approach is safe and efficient for non-extended pituitary surgery. Eur Arch Otorhinolaryngol 2020;277(4):1079–87. DOI: 10.1007/s00405-020-05790-6
12. Zhou Q., Yang Zh., Wang X. et al. risk factors and management of intraoperative cerebrospinal fluid leaks in endoscopic treatment of pituitary adenoma: analysis of 492 patients. World Neurosurg 2017;101:390–5. DOI: 10.1016/j.wneu.2017.01.119
13. Alekseev D.E., Alekseev E.D., Svistov D.V. Comparative analysis of the efficiency of dura mater defect repair in cerebral surgery. Zhurnal Voprosy neirokhirurgii im. N.N. Burdenko = Burdenko’s Journal of Neurosurgery 2018;82(5):48–54. (In russ.). DOI: 10.17116/neiro20188205148
14. Eseonu Ch.I., Refaey K., Rincon-Torroella J. et al. Еndoscopic versus microscopic transsphenoidal approach for pituitary adenomas: comparison of outcomes during the transition of methods of a single surgeon. World Neurosurg 2017;97:317–25. DOI: 10.1016/J.WNEu.2016.09.120
15. Burke W.T., Cote D.J., Iuliano S.I. et al. A practical method for prevention of readmission for symptomatic hyponatremia following transsphenoidal surgery. Pituitary 2018;21(1):25–31. DOI: 10.1007/s11102-017-0843-5
16. Trevisi G., Vigo V., Morena M.G. et al. Comparison of endoscopic versus microsurgical resection of pituitary adenomas with parasellar extension and evaluation of the predictive value of a simple 4-quadrant radiologic classification. World Neurosurg 2019;121:e769–e74. DOI: 10.1016/j.wneu.2018.09.215
17. Vasudevan K., Saad H., Oyesiku N.M. The role of three-dimensional endoscopy in pituitary adenoma surgery. Neurosurg Clin N Am 2019;30(4):421–32. DOI: 10.1016/j.nec.2019.05.012
18. Pigarova E.A., Dzeranova L.K., Zhukov A.Y. et al. Electrolyte disorders after endoscopic transnasal neurosurgical interventions. Endokrinnaia khirurgiia = Endocrine Surgery 2019;13(1):42–55. (In Russ.). DOI: 10.14341/serg10205
19. Farkhutdinova L., Valishina G. Postoperative hypopituitarism. Vrach = Doctor 2019;30(10):3–6. (In Russ.). DOI: 10.29296/25877305-2019-10-01
20. Abhinav K., Tyler M., Dale O.T. et al. Managing complications of endoscopic transsphenoidal surgery in pituitary adenomas. Exp rev Endocrinol Metabol 2020;15(5):311–9. DOI: 10.1080/17446651.2020.1800452
21. Upadhyay S., Buohliqah L., Dolci R.L.L. et al. Periodic olfactory assessment in patients undergoing skull base surgery with preservation of the olfactory strip. Laryngoscope 2017;127(9): 1970–5. DOI: 10.1002/lary.26546
22. Kawabata T., Takeuchi K., Nagata Y. et al. Preservation of olfactory function following endoscopic single nostril transseptal transsphenoidal surgery. World Neurosurg 2019;132:e665–e9 DOI: 10.1016/j.wneu.2019.08.051
23. Netuka D., Masopust V., Fundová P. et al. Olfactory results of endoscopic endonasal surgery for pituitary adenoma: a prospective study of 143 patients. World Neurosurg 2019;129: e907–e14. DOI: 10.1016/j.wneu.2019.05.061
24. Cossu G., Al-Taha K., Hajdu S.D. et al. Carotid-cavernous fistula after transsphenoidal surgery: a rare but challenging complication. World Neurosurg 2020;134:221–7. DOI: 10.1016/j.wneu.2019.10.194
25. Snyderman C., Kassam A., Carrau R. et al. Acquisition of surgical skills for endonasal skull base surgery: a training program. Laryngoscope 2007;117(4):699–705. DOI: 10.1097/MLg.0b013e318031c817
Review
For citations:
Skarubo A.N., Nikolenko V.N., Volel B.A., Zharikov Yu.O., Ivanchenko A.A., Zharikova T.S. Endonasal surgery for pituitary adenomas: surgical technique, intraoperative and postoperative complications. Russian journal of neurosurgery. 2025;27(3):152-161. (In Russ.) https://doi.org/10.63769/1683-3295-2025-27-3-152-161