Спонтанная назальная ликворея: обзор литературы
https://doi.org/10.17650/1683-3295-2024-26-1-137-147
Аннотация
Спонтанная назальная ликворея в силу редкости данной патологии и сложного этиопатогенеза остается недостаточно изученной. Схожесть клинической симптоматики с другими заболеваниями лор‑органов, низкая настороженность специалистов первичного звена приводят к несвоевременной диагностике и лечению, что обусловливает высокий риск развития осложнений. В последние годы проблематика диагностики и лечения этой патологии привлекает все больше внимания, о чем свидетельствует увеличение числа публикаций по данной теме.
В обзоре подробно рассмотрены вопросы этиопатогенеза, классификации, диагностики и лечения спонтанной назальной ликвореи на основе актуальных данных научной литературы.
Об авторах
В. А. Антипов
ГБУЗ г. Москвы «Городская клиническая больница им. В.В. Вересаева Департамента здравоохранения города Москвы»
Россия
Россия
127411 Москва, ул. Лобненская, 10
А. А. Каландари
ГБУЗ «Научно-исследовательский институт скорой помощи им. Н.В. Склифосовского Департамента здравоохранения города Москвы»
Россия
Россия
Алик Амиранович Каландари
129090 Москва, Большая Сухаревская пл., 3
Список литературы
1. Georgalas C., Oostra A., Ahmed S. et al. International Consensus Statement: spontaneous cerebrospinal fluid rhinorrhea. Int Forum Allergy Rhinol 2021;11(4):794–803. DOI: 10.1002/alr.22704
2. Wise S.K., Schlosser R.J. Evaluation of spontaneous nasal cerebrospinal fluid leaks. Curr Opin Otolaryngol Head Neck Surg 2007;15(1):28–34. DOI: 10.1097/MOO.0b013e328011bc76
3. Har-El G. What is “spontaneous” serebrospinal fluid rhinorrhea? Classification of cerebrospinal fluid leaks. Ann Otol Rhinol Laryngol 1999;108(4):323–6. DOI: 10.1177/000348949910800401
4. Mikayilli M., Hasanov T., Otluoglu G.D. et al. Spontaneous idiopathic cerebrospinal fluid rhinorrhea. J Craniofac Surg 2019;30(7):2265–7. DOI: 10.1097/SCS.0000000000005992
5. Giannetti A.V., de Morais Silva Santiago A.P., Becker H.M., Guimarães R.E. Comparative study between primary spontaneous cerebrospinal fluid fistula and late traumatic fistula. Otolaryngol Head Neck Surg 2011;144(3):463–8. DOI: 10.1177/0194599810391729
6. Ozdogan S., Gergin Y.E., Gergin S. et al. Spontaneous rhinorrhea mimicking sinusitis. Pan Afr Med J 2015;20:97. DOI: 10.11604/pamj.2015.20.97.5748
7. Filho B.C.A., Butugan O., Pádua F.G., Voegels R.L. Endoscopic repair of CSF rhinorrhea: experience of 44 cases. Braz J Oto rhinolaryngol 2005;71(4):472–6. DOI: 10.1016/S1808-8694(15)31202-7
8. Chen G.Y., Ma L., Xu M.L. et al. Spontaneous cerebrospinal fluid rhinorrhea: a case report and analysis. Medicine 2018;97(5):e9758. DOI: 10.1097/MD.0000000000009758
9. Liang C.-L., Lu K., Lee T.C. et al. Non-traumatic cerebrospinal fluid rhinorrhea indirectly caused by remote brain tumor: a case report and review of the literature. Clin Neurol Neurosurg 2001;103(2):83–6. DOI: 1016/S0303-8467(01)00118-4
10. Darouassi Y., Mliha Touati M., Chihani M. et al. Spontaneous cerebrospinal fluid leak of the sphenoid sinus mimicking allergic rhinitis, and managed successfully by a ventriculoperitoneal shunt: a case report. J Med Case Reports 2016;10(1):308. DOI: 10.1186/s13256-016-1107-0
11. Махмурян М.С. Спонтанная назальная ликворея (предрасполагающие факторы, диагностика и лечение). Дис. … канд. мед. наук. М., 2015. 256 с.
12. Rabbani C.C., Saltagi M.Z., Nelson R.F. The role of obesity, sleep apnea, and elevated intracranial pressure in spontaneous cerebrospinal fluid leaks. Curr Opin Otolaryngol Head Neck Surg 2019;27(5):349–55. DOI: 10.1097/MOO.0000000000000562
13. Stucken E.Z., Selesnick S.H., Brown K.D. The role of obesity in spontaneous temporal bone encephaloceles and CSF leak. Otol Neurotol 2012;33(8):1412–7. DOI: 10.1097/MAO.0b013e318268d350
14. Nelson R.F., Gantz B.J., Hansen M.R. The rising incidence of spontaneous cerebrospinal fluid leaks in the United States and the association with obesity and obstructive sleep apnea. Otol Neurotol 2015;36(3):476–80. DOI: 10.1097/MAO.0000000000000535
15. Bartier S., Verillaud B., Guichard J.P. et al. Anatomo-radiological study supporting the use of ipsilateral nasoseptal flap for the transpterygoid management of temporo-sphenoidal meningoceles. A review of 21 cases. Eur Ann Otorhinolaryngol Head Neck Dis 2020;137(1):37–42. DOI: 10.1016/j.anorl.2019.10.006
16. Barañano C.F., Curé J., Palmer J.N., Woodworth B.A. Sternberg’s canal: fact or fiction? Am J Rhinol Allergy 2009;137(1):167–71. DOI: 10.1016/j.anorl.2019.10.006
17. Illing E., Schlosser R.J., Palmer J.N. et al. Spontaneous sphenoid lateral recess cerebrospinal fluid leaks arise from intracranial hypertension, not Sternberg’s canal. Int Forum Allergy Rhinol 2014;4(3):246–50. DOI: 10.1002/alr.21262.
18. Englhard A.S., Volgger V., Leunig A. et al. Spontaneous nasal cerebrospinal fluid leaks: management of 24 patients over 11 years. Eur Arch Otorhinolaryngol 2018;275(10):2487–94. DOI: 10.1007/s00405-018-5089-y.
19. Settecase F., Harnsberger H.R., Michel M.A. et al. Spontaneous lateral sphenoid cephaloceles: anatomic factors contributing to pathogenesis and proposed classification. AJNR Am J Neuroradiol 2014;35(4):784–9. DOI: 10.3174/ajnr.A3744
20. Gonen L., Handzel O., Shimony N. et al. Surgical management of spontaneous cerebrospinal fluid leakage through temporal bone defects – case series and review of the literature. Neurosurg Rev 2016;39(1):141–50; discussion 150. DOI: 10.1007/s10143-015-0665-8.
21. Kutz J.W. Jr., Husain I.A., Isaacson B. et al. Management of spontaneous cerebrospinal fluid otorrhea. Laryngoscope 2008;118(12):2195–9. DOI: 10.1097/MLG.0b013e318182f833
22. Chaaban M.R., Illing E., Riley K.O., Woodworth B.A. Spontaneous cerebrospinal fluid leak repair: a five-year prospective evaluation. Laryngoscope 2014;124(1):70–5. DOI: 10.1002/lary.24160
23. Feng K., Qiuhang Z., Qiuyi Q. Transclival cerebrospinal fluid rhinorrhea as the initial presenting symptom of a tiny intradural chordoma. J Clin Neurosci 2010;17(8):1083–5. DOI: 10.1016/j.jocn.2009.12.012
24. Lieberman S.M., Chen S., Jethanamest D., Casiano R.R. Spontaneous CSF rhinorrhea: prevalence of multiple simultaneous skull base defects. Am J Rhinol Allergy 2015;29(1):77–81. DOI: 10.2500/ajra.2015.29.4121
25. Schlosser R.J., Bolger W.E. Spontaneous nasal cerebrospinal fluid leaks and empty sella syndrome: a clinical association. Am J Rhinol 2003;17(2):91–6.
26. Boyter E. Idiopathic intracranial hypertension. JAAPA 2019;32(5):30–5. DOI: 10.1097/01.JAA.0000554732.85914.91
27. Pérez M.A., Bialer O.Y., Bruce B.B. et al. Primary spontaneous cerebrospinal fluid leaks and idiopathic intracranial hypertension. J Neuroophthalmol 2013;3(4):330–7. DOI: 10.1097/WNO.0b013e318299c292
28. Brazis P. Clinical review: the surgical treatment of idiopathic pseudotumour cerebri (idiopathic intracranial hypertension). Cephalalgia 2008;28(12):1361–73. DOI: 10.1111/j.1468-2982.2008.01778.x
29. Martínez-Capoccioni G., Serramito-García R., Martín-Bailón M. et al. Spontaneous cerebrospinal fluid leaks in the anterior skull base secondary to idiopathic intracranial hypertension. Eur Arch Otorhinolaryngol 2017;274(5):2175–81. DOI: 10.1007/s00405-017-4455-5
30. Syed B.A. Nontraumatic (spontaneous) cerebrospinal fluid rhinorrhea from cribriform fistula associated with primary empty sella: report of two cases and literature review. Ann Saudi Med 2000;20(1):43–6. DOI: 10.5144/0256-4947.2000.43
31. Shetty P.G., Shroff M.M., Fatterpekar G.M. et al. A retrospective analysis of spontaneous sphenoid sinus fistula: MR and CT findings. AJNR Am J Neuroradiol 2000;21(2):337–42.
32. Tomazic P.V., Stammberger H. Spontaneous CSF-leaks and meningoencephaloceles in sphenoid sinus by persisting Sternberg’s canal. Rhinology 2009;47(4):369–74. DOI: 10.4193/Rhin08.236
33. Лопатин А.С., Сахокия Н.З., Гасымов Р.М. Спонтанная назальная ликворея и канал Штернберга: научные гипотезы и собственный опыт. Вестник оториноларингологии 2014;(1):70–4.
34. Abe D., Ogiwara T., Nakamura T. et al. Treatment strategy for giant invasive macroprolactinoma with spontaneous cerebrospinal fluid rhinorrhea: a case report and literature review. World Neurosurg 2020;144:19–23. DOI: 10.1016/j.wneu.2020.08.129
35. Ando S., Usuda H., Umeda Y. et al. [A case of chordoma presenting as recurrent bacterial meningitis with cerebrospinal fluid leakage (In Japanese)]. Rinsho Shinkeigaku 2019;59(5):264–7. DOI: 10.5692/clinicalneurol.cn-001272
36. Quiroz Tejada A.R., Simal-Julián J.A., Pérez de San Román-Mena L. et al. Spontaneous CSF rhinorrhea as a presenting symptom of a clival chordoma. Neurocirugia (Astur : Engl Ed). 2021;32(1):41–3. DOI: 10.1016/j.neucir.2019.12.002
37. Ozveren M.F., Kaplan M., Topsakal C. et al. Spontaneous cerebrospinal fluid rhinorrhea associated with chronic renal failure – case report. Neurol Med Chir (Tokyo) 2001;41(6):313–7. DOI: 10.2176/nmc.41.313
38. Woodside S.S., Metzler M.M. Pneumocephalus associated with inappropriate Valsalva technique. Aerosp Med Hum Perform 2019;90(6):566–9. DOI: 10.3357/AMHP.5363.2019.
39. Skedros D.G., Cass S.P., Hirsch B.E., Kelly R.H. Sources of error in use of beta-2 transferrin analysis for diagnosing perilymphatic and cerebral spinal fluid leaks. Otolaryngol Head Neck Surg 1993;109(5):861–4. DOI: 10.1177/019459989310900514
40. Chan D.T.M., Poon W.S., IP C.P. et al. How useful is glucose detection in diagnosing cerebrospinal fluid leak? The rational use of CT and Beta-2 transferrin assay in detection of cerebrospinal fluid fistula. Asian J Surg 2004;27(1):39–42. DOI: 10.1016/S1015-9584(09)60242-6
41. Shelesko E.V., Kravchuk A.D., Kapitanov D.N. et al. A modern approach to the diagnosis of nasal liquorrhea. Zhurnal Voprosy neirokhirurgii im. N.N. Burdenko = Burdenko’s Journal of Neurosurgery 2018;82(3):103–11. (In Russ., Eng.). DOI: 10.17116/neiro2018823103
42. Oakley G.M., Orlandi R.R., Woodworth B.A. et al. Diagnosis of management of cerebrospinal fluid rhinorrhea: an evidencebased review with recommendations. Int Forum Allergy Rhinol 2016;6(1):17–24. DOI: 10.1002/alr.21637.
43. Pool C.D., Patel V.A., Schilling A. et al. Economic implications of localization strategies for cerebrospinal fluid rhinorrhea. Int Forum Allergy Rhinol 2020;10(3):419–25. DOI: 10.1002/alr.22501
44. Eljazzar R., Loewenstern J., Dai J.B. et al. Detection of cerebrospinal fluid leaks: is there a radiologic standard of care? A systematic review. World Neurosurg 2019;127:307–15. DOI: 10.1016/j.wneu.2019.01.299.
45. Allensworth J.J., Rowan N.R., Storck K.A. et al. Endoscopic repair of spontaneous skull base defects decreases the incidence rate of intracranial complications. Int Forum Allergy Rhinol 2019;9(10):1089–96. DOI: 10.1002/alr.22399
46. Archer J.B., Sun H., Bonney P.A. et al. Extensive traumatic anterior skull base fractures with cerebrospinal fluid leak: classification and repair techniques using combined vascularized tissue flaps. J Neurosurg 2016;124(3):647–56. DOI: 10.3171/2015.4.JNS1528
47. Lesavoy M.A., Lee G.K., Fan K., Dickinson B. Split, temporalis muscle flap for repair of recalcitrant cerebrospinal fluid leaks of the anterior cranial fossa. J Craniofac Surg 2012;23(2):539–42. DOI: 10.1097/SCS.0b013e3182418f18
48. Lobo B.C., Baumanis M.M., Nelson R.F. Surgical repair of spontaneous cerebrospinal fluid (CSF) leaks: a systematic review. Laryngoscope Investig Otolaryngol 2017;2(5):215–24. DOI: 10.1002/lio2.75
49. Kveton J.F., Coelho D.H. Hydroxyapatite cement in temporal bone surgery: a 10 year experience. Laryngoscope 2004;114(1):33–7. DOI: 10.1097/00005537-200401000-00005
50. Locatelli D., Rampa F., Acchiardi I. et al. Endoscopic endonasal approaches for repair of cerebrospinal fluid leaks: nine-year experience. Neurosurgery 2006;58(4 Suppl_2):ONS-246–56; discussion ONS-256–7. DOI: 10.1227/01.NEU.0000193924.65297.3F
51. Fusetti S., Hammer B., Kellman R. et al. Endoscopic repair of CSF leak for Skull base fracture, central (anterior). Available at: https://surgeryreference.aofoundation.org/cmf/trauma/skull-base-cranialvault/skull-base-central-anterior/endoscopic-repair-of-csf-leak
52. Al-Nashar I.S., Carrau R.L., Herrera A., Snyderman C.H. Endoscopic transnasal transpterygopalatine fossa approach to the lateral recess of the sphenoid sinus. Laryngoscope 2004;114(3):528–32. DOI: 10.1097/00005537-200403000-00026
53. Doubi A.O., Aljomah D.S., Alhargan A.O., Alfawwaz F.S. The effect of lumbar drains on spontaneous cerebrospinal fluid leak repair. Neurosciences (Riyadh) 2018;23(4):281–5. DOI: 10.17712/nsj.2018.4.20180116
54. Hsu A.K., Singh A., Bury S. et al. Endoscopic cerebrospinal fluid leak closure in an infected field. Am J Rhinol Allergy 2015;29(4):305–8. DOI: 10.2500/ajra.2015.29.4171
55. Teachey W., Grayson J., Cho D.Y. et al. Intervention for elevated intracranial pressure improves success rate after repair of spontaneous cerebrospinal fluid leaks. Laryngoscope 2017;127(9):2011–16. DOI: 10.1002/lary.26612
56. Piper R.J., Kalyvas A.V., Young A.M. et al. Interventions for idiopathic intracranial hypertension. Cochrane Database Syst Rev 2015;8:CD003434. DOI: 10.1002/14651858.CD003434.pub3
57. Woodworth B.A., Prince A., Chiu A.G. et al. Spontaneous CSF leaks: a paradigm for definitive repair and management of intracranial hypertension. Otolaryngol Head Neck Surg 2008;138(6):715–20. DOI: 10.1016/j.otohns.2008.02.010
58. Kreatsoulas D.C., Shah V.S., Otto B.A. et al. Surgical outcomes of the endonasal endoscopic approach within a standardized management protocol for repair of spontaneous cerebrospinal fluid rhinorrhea. J Neurosurg 2020;134(3):780–6. DOI: 10.3171/2019.12.JNS192891
59. Schlosser R.J., Bolger W.E. Nasal cerebrospinal fluid leaks: critical review and surgical considerations. Laryngoscope 2004;114(2): 255–65. DOI: 10.1097/00005537-200402000-00015
Рецензия
Для цитирования:
Антипов В.А., Каландари А.А. Спонтанная назальная ликворея: обзор литературы. Нейрохирургия. 2024;26(1):137‑147. https://doi.org/10.17650/1683-3295-2024-26-1-137-147
For citation:
Antipov V.A., Kalandari A.A. Spontaneous cerebrospinal fluid rhinorrhea: literature review. Russian journal of neurosurgery. 2024;26(1):137‑147. (In Russ.) https://doi.org/10.17650/1683-3295-2024-26-1-137-147
Просмотров:
654
Послать статью по эл. почте 
