Combined treatment of recurrent glioblastoma (case report)
https://doi.org/10.17650/1683-3295-2020-22-2-72-78
Abstract
Malignant gliomas consist 15.6 % of all primary brain tumors. Amidst the group of neoplasms, glioblastoma remains the most common primary malignant brain tumor in adults. Mortality of patients with glioblastoma remains the highest among all cancer patients, approaching the absolute. At the present stage, a combined multimodal approach based on adjuvant chemotherapy and radiotherapy after the most safe microsurgical resection of the tumor is considered to be the standard protocol for the treatment of glioblastoma, but the median survival of patients does not exceed 24.5 months.
Recently, the role of stereotactic radiosurgery in the treatment of glioblastoma recurrence is increasing, which is due to the high efficiency and organ-preserving specifics of the radiosurgical effect. Our clinic uses stereotactic radiosurgery on the gamma knife, which is a successful combination of surgical and radio-oncological treatment technologies, using a high dose of focused radiation (in one or several procedures) and a sharp drop in the dose, which results in a pronounced radiobiological effect, along with a gentle attitude towards adjacent anatomical structures.
As part of this work, a clinical example of long-term survival with a high quality of life is given in the treatment of recurrent glioblastoma on the gamma knife.
About the Authors
A. S. Tokarev
N. V. Sklifosovsky Research Institute for Emergency Medicine, Moscow Healthcare Department
Russian Federation
Russian Federation
3 Bolshaya Sukharevskaya Sq., Moscow 129090
K. V. Gretskikh
N. V. Sklifosovsky Research Institute for Emergency Medicine, Moscow Healthcare Department
Russian Federation
Russian Federation
3 Bolshaya Sukharevskaya Sq., Moscow 129090
O. L. Viktorova
N. V. Sklifosovsky Research Institute for Emergency Medicine, Moscow Healthcare Department
Russian Federation
Russian Federation
3 Bolshaya Sukharevskaya Sq., Moscow 129090
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For citations:
Tokarev A.S., Gretskikh K.V., Viktorova O.L. Combined treatment of recurrent glioblastoma (case report). Russian journal of neurosurgery. 2020;22(2):72-78. (In Russ.) https://doi.org/10.17650/1683-3295-2020-22-2-72-78
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