Глубокая стимуляция головного мозга. Каким образом она контролирует движения при болезни Паркинсона?
https://doi.org/10.17650/1683-3295-2019-21-3-93-99
Аннотация
Методика глубокой стимуляции головного мозга (deep brain stimulation, DBS) предполагает имплантацию электродов в базальные ядра головного мозга. Дисрегуляция нейрональной активности именно в этих структурах считается причиной двигательных расстройств. DBS применяется при многих двигательных нарушениях (болезни Паркинсона, эссенциальном треморе, дистонии, тиках, тардивной дискинезии и др.), психических, поведенческих и аффективных расстройствах (депрессии, обсессивно-компульсивном расстройстве, эпилепсии и др.), а также при резистентных к медикаментозной терапии тяжелых болевых синдромах. Однако механизмы действия DBS не до конца изучены. В настоящее время рассматриваются различные теории и гипотезы, объясняющие механизм возникновения ее лечебного эффекта: частотная модель, теория «заклинивания», гипотезы о влиянии на нейрогенез, активности астроцитов, усилении мозгового кровотока, электротаксисе и др.
Об авторе
З. А. Залялова
ФГБОУ ВО «Казанский государственный медицинский университет» Минздрава России
Россия
Зулейха Абдуллазяновна Залялова
Россия
Зулейха Абдуллазяновна Залялова
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Рецензия
Для цитирования:
Залялова З.А. Глубокая стимуляция головного мозга. Каким образом она контролирует движения при болезни Паркинсона? Нейрохирургия. 2019;21(3):93-99. https://doi.org/10.17650/1683-3295-2019-21-3-93-99
For citation:
Zalyalova Z.A. Deep brain stimulation. How it controls movements in Parkinson’s disease? Russian journal of neurosurgery. 2019;21(3):93-99. (In Russ.) https://doi.org/10.17650/1683-3295-2019-21-3-93-99
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