The influence of clinical factors on postoperative life duration at patients with brain multiple metastases of malignant tumors
Abstract
Background and objective. Although surgery has traditionally been performed for patients with a single brain metastasis, an increasing number of patients with multiple brain metastases may also be treated surgically. The objective of the study was to analyse postoperative survival results and the clinical factors affecting them. Material and methods. The records of patients who underwent surgical resection of two or more lesions between January, 2005 and January, 2010 were retrospectively reviewed. Survival was calculated from the date of surgery to the last follow-up evaluation or death and different clinical factors were analyzed in regards to patient survival. Statistical analysis was performed using the SPSS and MedCalc for Windows software. Results. 36 patients underwent one or more craniotomies. Survival of entire group ranged from 16 days to 37,5 months (mean = 7,29 months). There were four death within 30 days. When divided into Radiation Therapy Group RPA classes, the survival rates were 11,75 , 8,58 and 5,31 month for Classes I, II and III, respectively. Regarding impact on survival statistically significant association with a favourable outcome was found for the following factors: number of brain metastases (2-3 vs. 4-6) p= 0,019 and radicality of metastases removal (all vs. partial) p= 0.018. Conclusions. Well-selected patients with multiple brain metastases appear to benefit from surgery.
About the Authors
K. Ya. Auslands
Рижская Восточная Клиническая Университетская больница, клиника «Гайлезерс»
Russian Federation
Russian Federation
Ju. V. Karlinia
Рижская Восточная Клиническая Университетская больница, клиника «Гайлезерс»
Russian Federation
Russian Federation
D. L. Apshkalis
Рижская Восточная Клиническая Университетская больница, клиники «Гайлезерс»
Russian Federation
Russian Federation
R. Ya. Ozols
Рижская Восточная Клиническая Университетская больница, клиника «Гайлезерс»
Russian Federation
Russian Federation
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Review
For citations:
Auslands K.Ya., Karlinia J.V., Apshkalis D.L., Ozols R.Ya. The influence of clinical factors on postoperative life duration at patients with brain multiple metastases of malignant tumors. Russian journal of neurosurgery. 2013;(1):31-35. (In Russ.)
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