The influence of hyperbaric oxygenation conducting under conditions of artificial lung ventilation on arterial blood gas at patients with intracranial hemorrhages

Objective. To study the dynamics of arterial blood gas at patients in critical state with intracranial hemorrhages during conduction of hyperbaric oxygenation (HBO) under conditions of artificial lung ventilation (ALV). Material and methods. We conducted the analysis of arterial blood gas and ratio of arterial pressure of oxygen (РаО) to fraction of inspired oxygen (FiO₂) (Р/F ratio) during 113 sessions of HBO under the conditions of ALV at 43 patients with intracranial hemorrhages. HBO was conducted in intensive care altitude chamber «Sechrist 2800» (USA), equipped with ALV apparatus «Sеchrist-500» (USA). Results. The conduction of HBO was accompanied by increase of РаО₂ from 178±44 till 195±55 mmHg - on 19,2 (9,2;30,8)% (р<0,05), РаСО₂ с 34±6,6 до 35,3±7 mmHg - on 3,8 (-1,2;6,9)% (р<0,05) and P/F ratio from 297±74 till 325±90 - on 9,8 (2,1;16,4)% (р<0,05). The best dynamics of РаО₂ and P/F ratio was revealed at patients with depression of consciousness level till 7-8 scores according to Glasgow Coma Scale. The significant dynamics of arterial blood gas during HBO conduction was not revealed at patients with initially normal pulmonary gas exchange. The increase of РаО₂ from 143±26 mmHg till 170±43,4 mmHg - on 21,2(9,8;31,4)% (р<0,05) and P/F ratio from 239±44 till 283±72 - on 19,8(3,3;30)% (р<0,05) at patients with acute lung injury. Conclusion. The received data testify that HBO conduction under the conditions of ALV at patients with intracranial hemorrhages is accompanied with evident increase of arterial pressure of oxygen and P/F ratio. The positive influence of HBO therapy on arterial blood oxygenation is the most expressed at patients with depression of consciousness level till 7-8 scores according to Glasgow Coma Scale and in case of acute lung injury.

гипербарическая оксигенация, внутричерепные кровоизлияния, искусственная вентиляция легких, газовый состав крови, hyperbaric oxygenation, intracranial hemorrhages, artificial lung ventilation, arterial blood gas

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