The local ozonotherapy in surgical treatment of brain echinococcus disease

Abstract

Objective was to improve the neurosurgical treatment outcomes at patients suffered from brain echinococcus disease. Material and methods. We observed 34 patients (20 women and 14 men) who was examined and treated because of brain echinococcus disease in neurosurgical department of National Hospital of Ministry of Public Health of Kyrgyz Republic within period from 2008 till 2013. The CT/MRI data revealed unicameral cysts at 21 (61,8%) patients; multiple (daughterly) cysts - at 8 (23,5%) patients; cysts with calcification - at 2 (5,9%) persons and parasitic cysts with decomposition and pus formation - at 3 (8,8%) patients. Results. The most patients in this study (24 (70,6%) among 34 persons) were operated on with the usage of ozonous normal saline solution (ONSS) for sanation of residual parasitic cavity. The residual cavity after removal of chitinous capsula of echinococcus cyst was filled by 10-15 mg/l ONSS and was packed by gauze pads. The exposure was 10-15 minutes with following removal of gauze pads and ONSS. The use of 10-15 mg/l ONSS leads to irreversible ultrastructural changes in germinal elements of echinococcus (hydatid cysts), whereby they lost the capability to generate the secondary cysts. The longer-term effects from ONSSS result in total (100%) destruction of echinococcus cell components. Conclusion. Ozon is the effective antiparasitic agent and can be used for desinfection of echinococcus residual cavities aimed to prevention of disease relapses.