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РЕГЕНЕРАТИВНЫЕ МЕТОДЫ ЛЕЧЕНИЯ ТРАВМЫ СПИННОГО МОЗГА. ОБЗОР ЛИТЕРАТУРЫ. ЧАСТЬ 1
Аннотация
Проблема лечения травматических повреждений спинного мозга – одна из наиболее сложных и актуальных в современной медицине. В подавляющем большинстве случаев травма спинного мозга (ТСМ) приводит к стойкой инвалидизации пациентов, что имеет как медико-социальные, так и экономические последствия для пациента, его семьи и государства. Современные методы лечения ТСМ обладают крайне ограниченной эффективностью и не позволяют в достаточной степени восстановить утраченные функции центральной нервной системы. Регенеративные методы и, в частности, клеточная терапия – очень многообещающее направление, дающее надежду на эффективное лечение ТСМ. В обзоре освещены проблемы эпидемиологии и патогенеза ТСМ, описаны существующие методы терапии, а также перспективные методы регенеративной терапии. Особое внимание уделено результатам доклинических и клинических исследований в области клеточной терапии. Обзор разделен на 4 части. В 1-й части освещаются эпидемиология и патогенез ТСМ, а также хирургические, физические, фармакологические методы ее лечения.
Ключевые слова
Об авторах
В. А. Смирнов
ГБУЗ «Научно-исследовательский институт скорой помощи им. Н.В. Склифосовского Департамента здравоохранения г. Москвы»
Россия
129090 Москва, Большая Сухаревская пл., 3
Россия
129090 Москва, Большая Сухаревская пл., 3
А. А. Гринь
ГБУЗ «Научно-исследовательский институт скорой помощи им. Н.В. Склифосовского Департамента здравоохранения г. Москвы»; ФГБОУ ВО «Московский государственный медико-стоматологический университет им. А.И. Евдокимова» Минздрава России
Россия
Россия
129090 Москва, Большая Сухаревская пл., 3;
127473 Москва, ул. Делегатская, 20, стр. 1
В. В. Крылов
ГБУЗ «Научно-исследовательский институт скорой помощи им. Н.В. Склифосовского Департамента здравоохранения г. Москвы»; ФГБОУ ВО «Московский государственный медико-стоматологический университет им. А.И. Евдокимова» Минздрава России
Россия
Россия
129090 Москва, Большая Сухаревская пл., 3;
127473 Москва, ул. Делегатская, 20, стр. 1
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Для цитирования:
Смирнов В.А., Гринь А.А., Крылов В.В. РЕГЕНЕРАТИВНЫЕ МЕТОДЫ ЛЕЧЕНИЯ ТРАВМЫ СПИННОГО МОЗГА. ОБЗОР ЛИТЕРАТУРЫ. ЧАСТЬ 1. Нейрохирургия. 2019;21(2):66-75. https://doi.org/10.17650/1683-3295-2019-21-2-66-75
For citation:
Smirnov V.А., Grin А.А., Krylov V.V. REGENERATIVE TREATMENT OF SPINAL CORD INJURY. LITERATURE REVIEW. PART 1. Russian journal of neurosurgery. 2019;21(2):66-75. (In Russ.) https://doi.org/10.17650/1683-3295-2019-21-2-66-75
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