COVID-19-associated frontal bone osteomyelitis. Clinical case and literature review
https://doi.org/10.17650/1683-3295-2024-26-1-92-98
Abstract
COVID‑19‑associated osteomyelitis is a purulo‑necrotic complication of past coronaviral infection. The majority of described cases of this complication are caused by Mucorales fungi. Mucormycosis is a severe complication of COVID‑19 associated with high mortality rate. Most commonly it affects maxillary sinuses, facial bones, and orbits. Due to quick progression of the disease, it is important to remember the association between COVID‑19 infection and purulo‑necrotic lesions of the skull that can be complicated by brain involvement.
The article presents a very rare observation of COVID‑19‑associated osteomyelitis affecting the squamous part of the frontal bone complicated by formation of bilateral symmetrical subgaleal abscesses in the projection of the frontal eminences.
About the Authors
G. Yu. EvzikovRussian Federation
Bld. 1, 11 Rossolimo St., Moscow 119021
D. Yu. Neretin
Russian Federation
Daniil Yuryevich Neretin
Bld. 1, 11 Rossolimo St., Moscow 119021
References
1. Baranova I.B., Yaremenko A.I., Zubareva A.A. et al. Mucormycosis of the bones of the facial skull, nasal cavity and paranasal sinuses in patients with COVID-19. Klinicheskaya mikrobiologiya i antimikrobnaya khimioterpiya = Clinical Microbiology and Antimicrobial Chemotherapy 2021;23(4):347–58. (In Russ.). DOI: 10.36488/cmac.2021.4.347-358
2. Hussain S., Riad A., Singh A. et al. Global prevalence of COVID-19-associated mucormycosis (CAM): living systematic review and meta-analysis. J Fungi (Basel) 2021;7(11):985. DOI: 10.3390/jof7110985
3. Elmokadem A.H., Bayoumi D., Mansour M. et al. COVID-19associated acute invasive fungal sinusitis: clinical and imaging findings. J Neuroimaging 2022;32(4):676–89. DOI: 10.1111/jon.12967
4. Muthu V., Rudramurthy S.M., Chakrabarti A., Agarwal R. Epidemiology and pathophysiology of COVID-19-associated mucormycosis: India versus the rest of the world. Mycopathologia 2021;186(6):739–54. DOI: 10.1007/s11046-021-00584-8
5. Dar-Odeh N., Bobamuratova D.T., Alnazzawi A. et al. Jaw-related complications in COVID-19 patients; a systematic review. Cranio 2022:1–8. Online ahead of print. DOI: 10.1080/08869634.2022.2031438
6. Nasir N., Farooqi J., Mahmood S.F., Jabeen K. COVID-19 associated mucormycosis: a life-threatening complication in patients admitted with severe to critical COVID-19 from Pakistan. Clin Microbiol Infect 2021;27(11):1704–7. DOI: 10.1016/j.cmi.2021.07.038
7. Prakash H., Chakrabarti A. Global epidemiology of mucormycosis. J Fungi (Basel) 2019;5(1):26. DOI: 10.3390/jof5010026
8. Rudramurthy S.M., Hoenigl M., Meis J.F. et al. ECMM/ISHAM recommendations for clinical management of COVID-19 associated mucormycosis in low-and middle-income countries. Mycoses 2021;64(9):1028–37. DOI: 10.1111/myc.13335
9. Selarka L., Sharma S., Saini D. et al. Mucormycosis and COVID-19: an epidemic within a pandemic in India. Mycoses 2021;64(10):1253–60. DOI: 10.1111/myc.13353
10. Song G., Liang G., Liu W. Fungal co-infections associated with global COVID-19 pandemic: a clinical and diagnostic perspective from China. Mycopathologia 2020;185(4):599–606. DOI: 10.1007/s11046-020-00462-9
11. Amonov Sh., Karshiev Kh., Enazarov D., Normuminov F. Therapeutic tactics in patients with post-COVID purulentinflammatory complications of the maxillofacial region. Stomatologiya = Dentistry 2021;82(1):92–5. (In Russ.). DOI: 10.34920/2091-5845-2021-30
12. Ubaidullaev M.B., Suleymanov A.M., Agaidarova G.M. PostCOVID syndrome. Cases from practice. Chronic osteomyelitis of the upper jaw. Meditsina i innovatsii = Medicine and Innovation 2021;1(4):333–6. (In Russ.).
13. Bobamuratova D.T., Boymuradov Sh.A., Dar-Odeh N.S. et al. Impact of COVID-19 disease and its treatment on the development of maxillofacial complications. Adv Oral Maxillofac Surg 2021;4(10):100169. DOI: 10.1016/j.adoms.2021.100169
14. El-Kholy N.A., El-Fattah A.M.A., Khafagy Y.W. Invasive fungal sinusitis in post COVID-19 patients: a new clinical entity. Laryngoscope 2021;131(12):2652–8. DOI: 10.1002/lary.29632
15. Singh A.K., Singh R., Joshi S.R., Misra A. Mucormycosis in COVID-19: a systematic review of cases reported worldwide and in India. Diabetes Metab Syndr 2021;15(4):102146. DOI: 10.1016/j.dsx.2021.05.019
16. Jindal G., Sethi A., Bhargarva K. et al. Imaging findings in invasive rhino-orbito-cerebral mucormycosis in post-COVID-19 patients. Proc (Bayl Univ Med Cent) 2021;35(1):32–4. DOI: 10.1080/08998280.2021.1981100
17. Kondapavuluri S.K., Anchala V.K.R., Bandlapalli S. et al. Spectrum of MR imaging findings of sinonasalmucormycosis in post COVID-19 patients. Br J Radiol 2021;94(1127):20210648. DOI: 10.1259/bjr.20210648
18. Hoenigl M., Seidel D., Carvalho A. et al. The emergence of COVID-19 associated mucormycosis: a review of cases from 18 countries. Lancet Microbe 2022;3(7):e543–e52. DOI: 10.1016/S2666-5247(21)00237-8
19. Eswaran S., Balan S.K., Saravanam P.K. Acute fulminant mucormycosis triggered by Covid 19 infection in a young patient. Indian J Otolaryngol Head Neck Surg 2022;74(Suppl 2):3442–6. DOI: 10.1007/s12070-021-02689-4
Review
For citations:
Evzikov G.Yu., Neretin D.Yu. COVID-19-associated frontal bone osteomyelitis. Clinical case and literature review. Russian journal of neurosurgery. 2024;26(1):92‑98. https://doi.org/10.17650/1683-3295-2024-26-1-92-98