References

neurosurgery

Нейрохирургия

Russian journal of neurosurgery

1683-32952587-7569

Издательский дом "МедИНК"

10.17650/1683-3295-2019-21-3-93-99

neurosurgery-751

Research Article

ОБЗОРЫ ЛИТЕРАТУРЫ

LITERATURE REVIEW

Глубокая стимуляция головного мозга. Каким образом она контролирует движения при болезни Паркинсона?

Deep brain stimulation. How it controls movements in Parkinson’s disease?

https://orcid.org/0000-0001-8718-7266

Залялова

З. А.

Zalyalova

Z. A.

Зулейха Абдуллазяновна Залялова

z.zalyalova@gmail.com

ФГБОУ ВО «Казанский государственный медицинский университет» Минздрава РоссииРоссияKazan State Medical University, Ministry of Health of RussiaRussian Federation

2019

14092019

2139399

2019

Залялова З.А.

Zalyalova Z.A.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.therjn.com/jour/article/view/751

Методика глубокой стимуляции головного мозга (deep brain stimulation, DBS) предполагает имплантацию электродов в базальные ядра головного мозга. Дисрегуляция нейрональной активности именно в этих структурах считается причиной двигательных расстройств. DBS применяется при многих двигательных нарушениях (болезни Паркинсона, эссенциальном треморе, дистонии, тиках, тардивной дискинезии и др.), психических, поведенческих и аффективных расстройствах (депрессии, обсессивно-компульсивном расстройстве, эпилепсии и др.), а также при резистентных к медикаментозной терапии тяжелых болевых синдромах. Однако механизмы действия DBS не до конца изучены. В настоящее время рассматриваются различные теории и гипотезы, объясняющие механизм возникновения ее лечебного эффекта: частотная модель, теория «заклинивания», гипотезы о влиянии на нейрогенез, активности астроцитов, усилении мозгового кровотока, электротаксисе и др.

Deep brain stimulation (DBS) involves implantation of electrodes in the basal ganglia of the brain. Dysregulation of neuronal activity in these structures is the cause of motor disorders. DBS is used in many motor (Parkinson’s disease, essential tremor, dystonia, ticks, tardive dyskinesia and others), psychological, behavioral and affective (depression, obsessive-compulsive disorder, epilepsy and others) disorders, as well as in severe pain syndromes resistant to drug therapy. However, the mechanisms of action of DBS are not fully understood. Currently, different theories and hypotheses are considered which explain its mechanism of treatment: rate model, “jamming” theory, hypotheses about the effect on neurogenesis, astrocyte activity, increased brain circulation, electrotaxis, etc.

болезнь Паркинсонадистониядискинезияглубокая стимуляция головного мозгабазальные ганглиисубталамическое ядронейромодуляциясинаптическая пластичность

Parkinson’s diseasedystoniadyskinesiadeep brain stimulationbasal gangliasubthalamic nucleusneuromodulationsynaptic plasticity

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The authors declare that there are no conflicts of interest present.