neurosurgeryНейрохирургияRussian journal of neurosurgery1683-32952587-7569Издательский дом "МедИНК"10.17650/1683-3295-2019-21-3-83-92neurosurgery-750Research ArticleОБЗОРЫ ЛИТЕРАТУРЫLITERATURE REVIEWРегенеративные методы лечения травмы спинного мозга. Обзор литературы. Часть 2Regenerative treatment of spinal cord injury. Literature review. Part 2https://orcid.org/0000-0003-4096-1087СмирновВ. А.SmirnovV. A.

Владимир Александрович Смирнов

vla_smirnov@mail.ruhttps://orcid.org/0000-0003-3515-8329ГриньА. А.GrinA. A.ГБУЗ «Научно-исследовательский институт скорой помощи им. Н.В. Склифосовского Департамента здравоохранения г. Москвы»; ФГБОУ ВО «Московский государственный медико-стоматологический университет им. А.И. Евдокимова» Минздрава РоссииРоссияN.V. Sklifosovsky Research Institute for Emergency Medicine, Moscow Healthcare DepartmentRussian FederationГБУЗ «Научно-исследовательский институт скорой помощи им. Н.В. Склифосовского Департамента здравоохранения г. Москвы»РоссияN.V. Sklifosovsky Research Institute for Emergency Medicine, Moscow Healthcare Department; A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of RussiaRussian Federation2019140920192138392Copyright © Смирнов В.А., Гринь А.А., 20192019Смирнов В.А., Гринь А.А.Smirnov V.A., Grin A.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.therjn.com/jour/article/view/750

Проблема лечения травматических повреждений спинного мозга – одна из наиболее сложных и актуальных для современной медицины. В подавляющем большинстве случаев травма спинного мозга (ТСМ) приводит к стойкой инвалидизации пациентов, что имеет как медико-социальные, так и экономические последствия для пациента, его семьи и государства. Современные методы лечения ТСМ обладают крайне ограниченной эффективностью и не позволяют в достаточной степени восстановить утраченные функции центральной нервной системы. Регенеративные методы и, в частности, клеточная терапия – очень многообещающее направление, дающее надежду на эффективное лечение ТСМ. В обзоре освещены проблемы эпидемиологии и патогенеза ТСМ, описаны существующие методы терапии, а также перспективные методы регенеративной терапии. Особое внимание уделено результатам доклинических и клинических исследований в области клеточной терапии. Обзор разделен на 4 части. Во 2-й части описаны методы регенеративной терапии неклеточного происхождения и клеточной терапии.

Treating traumatic spinal cord injuries is one of the most complicated and relevant problems in the modern medicine. In the vast majority of cases spinal cord injury (SCI) leads to persistent disability, with medical, social and economic consequences ensuing for the patient, the family and the state. Modern SCI therapy has a very limited effectiveness and does not allow to sufficiently restore the lost functions of central nervous system. Regenerative methods and particularly cell therapy are very promising to effectively treat SCI. The review highlights SCI epidemiological and pathogenetic problems, existing therapy, as well as promising methods of regenerative therapy. We emphasize the results of preclinical and clinical studies in the field of cell therapy. The review is divided into 4 parts. Part 2 describes the methods of noncellular regenerative therapy and cell therapy.

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The authors declare that there are no conflicts of interest present.