Материалы и методы

neurosurgery

Нейрохирургия

Russian journal of neurosurgery

1683-32952587-7569

Издательский дом "МедИНК"

10.17650/1683-3295-2019-21-3-73-82

neurosurgery-749

Research Article

ЛЕКЦИЯ

LECTURE

Первичные герминогенные опухоли центральной нервной системы

Primary germ cell tumors of the central nervous system

https://orcid.org/0000-0002-8459-2466

Мартынов

Б. В.

Martynov

B. V.

https://orcid.org/0000-0002-2769-3551

Мартынов

Р. С.

Martynov

R. S.

Роман Сергеевич Мартынов

rs_martin@mail.ru

https://orcid.org/0000-0002-3922-9887

Свистов

Д. В.

Svistov

D. V.

ФГБВОУ ВО «Военно-медицинская академия им. С.М. Кирова» Минобороны РоссииРоссияS.M. Kirov Military Medical Academy, Ministry of Defense of RussiaRussian Federation

2019

14092019

2137382

2019

Мартынов Б.В., Мартынов Р.С., Свистов Д.В.

Martynov B.V., Martynov R.S., Svistov D.V.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.therjn.com/jour/article/view/749

Цель исследования – описать современные взгляды на патогенез, особенности молекулярной биологии, диагностику, лечение первичных герминогенных опухолей центральной нервной системы, а также прогноз их лечения.

Материалы и методы

Материалы и методы. В обзор включен 51 источник литературы (4 русскоязычных и 47 англоязычных). Все работы были опубликованы в течение последних 20 лет.

Результаты и заключение

Результаты и заключение. В настоящем обзоре отражены как общепринятые положения, так и особенности национального протокола лечения герминогенных опухолей, нюансы лечения, определяемые гистологическим типом опухоли. Наиболее эффективным методом лечения гермином считается лучевая и неоадъювантная химиотерапия. Для негерминомных герминогенных опухолей оптимальна химиотерапия и облучение с последующим тотальным удалением. Тотальная резекция опухоли сама по себе – идеальный метод лечения зрелых тератом. Проведение молекулярных и цитогенетических исследований позволит дополнительно выделить различные подтипы герминогенных опухолей центральной нервной системы, что станет основой для новых направлений терапии, улучшения результатов лечения и методов прогнозирования.

The study objective is to describe current views on pathogenesis, molecular biology, diagnosis, treatment of primary germ cell tumors of the central nervous system, as well as treatment prognosis.

Materials and methods

Materials and methods. The review includes 51 literature sources (4 in Russian, 47 in English). All articles were published in the last 20 years.

Results and conclusion

Results and conclusion. The review reflects both established principles and characteristics of the national protocol of treatment of germ cell tumors, treatment nuances determined by histological type of the tumor. The most effective treatment method for germ cell tumors are radiation and neoadjuvant chemotherapy. For non-germinal germ cell tumors chemotherapy with subsequent complete removal is optimal. Total tumor resection by itself is the ideal treatment of mature teratomas. In the future, molecular and cytogenetic studies will allow to additionally identify subtypes of germ cell tumors of the central nervous system which will become the basis of new directions for therapy, improved treatment results and methods of prognosis.

герминогенные опухолигерминоматератомаэмбриональная карциномахориокарциномаопухоль желточного мешкапатогенездиагностикалечениепрогноз

germinomateratomaembryonal carcinomachoriocarcinomayolk sac tumorspathogenesisdiagnosistreatmentprognosis

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The authors declare that there are no conflicts of interest present.