neurosurgeryНейрохирургияRussian journal of neurosurgery1683-32952587-7569Издательский дом "МедИНК"10.17650/1683-3295-2019-21-2-94-106neurosurgery-724Research ArticleОБЗОРЫ ЛИТЕРАТУРЫLITERATURE REVIEWГИПОТАЛАМИЧЕСКАЯ ГАМАРТОМА: ОБЗОР ЛИТЕРАТУРЫHYPOTHALAMIC HAMARTOMA. LITERATURE REVIEWhttps://orcid.org/0000-0002-9575-4520ГригорьевА. Ю.GrigorievА. Yu.

127473 Москва, ул. Делегатская, 20, стр. 1;

117036 Москва, ул. Дмитрия Ульянова, 11

Bld. 1, 20 Delegatskaya St., Moscow 127473;

11 Dmitriya Ul’yanova St., Moscow 117036

https://orcid.org/0000-0001-5026-0060СинкинМ. В.SinkinМ. V.https://orcid.org/0000-0001-8207-7180ГригорьеваЕ. В.GrigorievaЕ. V.

127473 Москва, ул. Делегатская, 20, стр. 1

https://orcid.org/0000-0002-6911-0975ТрифоновИ. С.TrifonovI. S.

127473 Москва, ул. Делегатская, 20, стр. 1

dr.trifonov@mail.ruФГБОУ ВО «Московский государственный медико-стоматологический университет им. А.И. Евдокимова» Минздрава России; ФГБУ «Национальный медицинский исследовательский центр эндокринологии» Минздрава РоссииРоссияA.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia; National Medical Research Center of Endocrinology, Ministry of Health of RussiaRussian FederationГБУЗ «Научно-исследовательский институт скорой помощи им. Н.В. Склифосовского Департамента здравоохранения г. Москвы»РоссияN.V. Sklifosovsky Research Institute for Emergency Medicine, Moscow Healthcare DepartmentRussian FederationФГБОУ ВО «Московский государственный медико-стоматологический университет им. А.И. Евдокимова» Минздрава РоссииРоссияA.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of RussiaRussian Federation20191606201921294106Copyright © Григорьев А.Ю., Синкин М.В., Григорьева Е.В., Трифонов И.С., 20192019Григорьев А.Ю., Синкин М.В., Григорьева Е.В., Трифонов И.С.Grigoriev А.Y., Sinkin М.V., Grigorieva Е.V., Trifonov I.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.therjn.com/jour/article/view/724

Цель исследования – провести анализ научной литературы, посвященной вопросам диагностики и лечения гипоталамических гамартом. Материалы и методы. Изучены данные 90 научных источников, опубликованных в 1948–2019 гг. Результаты. Описана клиническая картина гипоталамических гамартом, разнообразные их классификации, особенности нейровизуализационных и нейрофизиологических методов диагностики, патоморфологического исследования, а также способы хирургического лечения. Заключение. Трансназальное удаление – перспективный минимально инвазивный метод лечения гипоталамических гамартом IV и V типов по классификации J. Régis и соавт. Согласно данным научной литературы, для удаления I–IV типов гамартом могут быть применены стереотаксические методы деструкции, для II и III типов методом выбора считается эндоскопический трансвентрикулярный доступ, а при IV и V типах может быть выполнено трансназальное транссфеноидальное эндоскопическое удаление.

The study objective is to analyze scientific literature on hypothalamic hamartomas’ diagnostics and treatment. Materials and methods. We studied 90 scientific sources, published between 1948 and 2019. Results. The paper describes clinical picture of hypothalamic hamartomas, their various classifications, specificity of neuroimaging and neurophysiological diagnostics and pathomorphological research, the surgical treatment. Conclusion. Transnasal resection is a promising and noninvasive method to treat hypothalamic hamartomas of IV and V types by J. Régis classification. According to the scientific literature, stereotactic destruction can be used to resect hamartomas of I–IV types; types II and III require endoscopic transventricular approach, while types IV and V can be resected using endoscopic transnasal transsphenoidal approach.

гипоталамическая гамартомахирургическое лечениедиагностикастереотаксическая радиочастотная термокоагуляцияэндоскопиятрансвентрикулярный доступтрансназальный транссфеноидальный доступтомографияhypothalamic hamartomasurgical therapydiagnosticsstereotactic radiofrequency thermocoagulationendoscopytransventricular approachtransnasal transsphenoidal approachtomographyReferencesAlves C., Barbosa V., Machado M. Giant hypothalamic hamartoma: case report and literature review. Childs Nerv Syst 2013;29(3):513–6. DOI: 10.1007/s00381-013-2022-y.Alves C., Barbosa V., Machado M. Giant hypothalamic hamartoma: case report and literature review. Childs Nerv Syst 2013;29(3):513–6. DOI: 10.1007/s00381-013-2022-y.Brandberg G., Raininko R., Eeg-Olofsson O. Hypothalamic hamartoma with gelastic seizures in Swedish children and adolescents. Eur J Paediatr Neurol 2004;8(1):35–44. DOI: 10.1016/j.ejpn.2003.10.003.Brandberg G., Raininko R., Eeg-Olofsson O. Hypothalamic hamartoma with gelastic seizures in Swedish children and adolescents. Eur J Paediatr Neurol 2004;8(1):35–44. DOI: 10.1016/j.ejpn.2003.10.003.Delalande O., Fohlen M. Disconnecting surgical treatment of hypothalamic hamartoma in children and adults with refractory epilepsy and proposal of a new classification. Neurol Med Chir (Tokyo) 2003;43(2):61–8.Delalande O., Fohlen M. Disconnecting surgical treatment of hypothalamic hamartoma in children and adults with refractory epilepsy and proposal of a new classification. Neurol Med Chir (Tokyo) 2003;43(2):61–8.Craig D.W., Itty A., Panganiban C. et al. Identification of somatic chromosomal abnormalities in hypothalamic hamartoma tissue at the GLI3 locus. Am J Hum Genet 2008;82(2):366–74. DOI: 10.1016/j.ajhg.2007.10.006.Craig D.W., Itty A., Panganiban C. et al. Identification of somatic chromosomal abnormalities in hypothalamic hamartoma tissue at the GLI3 locus. Am J Hum Genet 2008;82(2):366–74. DOI: 10.1016/j.ajhg.2007.10.006.Hall J.G., Pallister P.D., Clarren S.K. et al. Congenital hypothalamic hamartoblastoma, hypopituitarism, imperforate anus and postaxial polydactyly – a new syndrome? Part I: clinical, causal, and pathogenetic considerations. Am J Med Genet 1980;7(1):47–74. DOI: 10.1002/ajmg.1320070110.Hall J.G., Pallister P.D., Clarren S.K. et al. Congenital hypothalamic hamartoblastoma, hypopituitarism, imperforate anus and postaxial polydactyly – a new syndrome? Part I: clinical, causal, and pathogenetic considerations. Am J Med Genet 1980;7(1):47–74. DOI: 10.1002/ajmg.1320070110.Al-Hail H.J. et al. Hypothalamic hamartoma presenting with gelastic seizures, generalized convulsions, and ictal psychosis. Neurosciences (Riyadh) 2010;15(1):43–5.Al-Hail H.J. et al. Hypothalamic hamartoma presenting with gelastic seizures, generalized convulsions, and ictal psychosis. Neurosciences (Riyadh) 2010;15(1):43–5.Boyko O.B., Curnes J.T., Oakes W.J., Burger P.C. Hamartomas of the tuber cinereum: CT, MR, and pathologic findings. AJNR Am J Neuroradiol 1991;12(2):309–14.Boyko O.B., Curnes J.T., Oakes W.J., Burger P.C. Hamartomas of the tuber cinereum: CT, MR, and pathologic findings. AJNR Am J Neuroradiol 1991;12(2):309–14.Mahachoklertwattana P., Kaplan S.L., Grumbach M.M. The luteinizing hormone-releasing hormone-secreting hypothalamic hamartoma is a congenital malformation: natural history. J Clin Endocrinol Metab 1993;77(1):118–24. DOI: 10.1210/jcem.77.1.8325933.Mahachoklertwattana P., Kaplan S.L., Grumbach M.M. The luteinizing hormone-releasing hormone-secreting hypothalamic hamartoma is a congenital malformation: natural history. J Clin Endocrinol Metab 1993;77(1):118–24. DOI: 10.1210/jcem.77.1.8325933.Valdueza J.M., Cristante L., Dammann O. et al. Hypothalamic hamartomas: with special reference to gelastic epilepsy and surgery. Neurosurgery 1994;34(6):949–58.Valdueza J.M., Cristante L., Dammann O. et al. Hypothalamic hamartomas: with special reference to gelastic epilepsy and surgery. Neurosurgery 1994;34(6):949–58.Arita K., Ikawa F., Kurisu K. et al. The relationship between magnetic resonance imaging findings and clinical manifestations of hypothalamic hamartoma. J Neurosurg 1999;91(2):212–20. DOI: 10.3171/jns.1999.91.2.0212.Arita K., Ikawa F., Kurisu K. et al. The relationship between magnetic resonance imaging findings and clinical manifestations of hypothalamic hamartoma. J Neurosurg 1999;91(2):212–20. DOI: 10.3171/jns.1999.91.2.0212.Choi J.U., Yang K.H., Kim T.G. et al. Endoscopic disconnection for hypothalamic hamartoma with intractable seizure. Report of four cases. J Neurosurg 2004;100(5 Suppl Pediatrics):506–11. DOI: 10.3171/ped.2004.100.5.0506.Choi J.U., Yang K.H., Kim T.G. et al. Endoscopic disconnection for hypothalamic hamartoma with intractable seizure. Report of four cases. J Neurosurg 2004;100(5 Suppl Pediatrics):506–11. DOI: 10.3171/ped.2004.100.5.0506.Li C.D., Luo S.Q., Tang J. et al. Classification of hypothalamic hamartoma and prognostic factors for surgical outcome. Acta Neurol Scand 2014;130(1):18–26. DOI: 10.1111/ane.12209.Li C.D., Luo S.Q., Tang J. et al. Classification of hypothalamic hamartoma and prognostic factors for surgical outcome. Acta Neurol Scand 2014;130(1):18–26. DOI: 10.1111/ane.12209.Régis J., Scavarda D., Tamura M. et al. Gamma knife surgery for epilepsy related to hypothalamic hamartomas. Semin Pediatr Neurol 2007;14(2):73–9. DOI: 10.1016/j.spen 2007.03.005.Régis J., Scavarda D., Tamura M. et al. Gamma knife surgery for epilepsy related to hypothalamic hamartomas. Semin Pediatr Neurol 2007;14(2):73–9. DOI: 10.1016/j.spen 2007.03.005.Shahar E., Kramer U., Mahajnah M. et al. Pediatric-onset gelastic seizures: clinical data and outcome. Pediatr Neurol 2007; 37(1):29–34. DOI: 10.1016/ j pediatrneurol.2007.03.003.Shahar E., Kramer U., Mahajnah M. et al. Pediatric-onset gelastic seizures: clinical data and outcome. Pediatr Neurol 2007; 37(1):29–34. DOI: 10.1016/ j pediatrneurol.2007.03.003.Parvizi J., Le S., Foster B.L. et al. Gelastic epilepsy and hypothalamic hamartomas: neuroanatomical analysis of brain lesions in 100 patients. Brain 2011;134(Pt 10): 2960–8. DOI: 10.1093/brain/awr235.Parvizi J., Le S., Foster B.L. et al. Gelastic epilepsy and hypothalamic hamartomas: neuroanatomical analysis of brain lesions in 100 patients. Brain 2011;134(Pt 10): 2960–8. DOI: 10.1093/brain/awr235.Trousseau A. De l’epilepsie. Clinique Medicale de L’Hotel-Dieu de Paris. Paris, 1877. Pp. 89–155.Trousseau A. De l’epilepsie. Clinique Medicale de L’Hotel-Dieu de Paris. Paris, 1877. Pp. 89–155.Daly D.D., Mulder D.W. Gelastic epilepsy. Neurology 1957;7(3):189–92.Daly D.D., Mulder D.W. Gelastic epilepsy. Neurology 1957;7(3):189–92.Gascon G.G., Lombroso C.T. Epileptic (gelastic) laughter. Epilepsia 1971;12(1):63–76. DOI: 10.1111/j.1528-1157.1971.tb03916.x.Gascon G.G., Lombroso C.T. Epileptic (gelastic) laughter. Epilepsia 1971;12(1):63–76. DOI: 10.1111/j.1528-1157.1971.tb03916.x.Tran T.P., Truong V.T., Wilk M. et al. Different localizations underlying cortical gelastic epilepsy: case series and review of literature. Epilepsy Behav 2014;35:34–41. DOI: 10.1016/j. yebeh. 2014.03.024.Tran T.P., Truong V.T., Wilk M. et al. Different localizations underlying cortical gelastic epilepsy: case series and review of literature. Epilepsy Behav 2014;35:34–41. DOI: 10.1016/j. yebeh. 2014.03.024.Kameyama S., Masuda H., Murakami H. Ictogenesis and symptomatogenesis of gelastic seizures in hypothalamic hamartomas: an ictal SPECT study. Epilepsia 2010;51(11):2270–9. DOI: 10.1111/j.1528-1167.2010.02739.x.Kameyama S., Masuda H., Murakami H. Ictogenesis and symptomatogenesis of gelastic seizures in hypothalamic hamartomas: an ictal SPECT study. Epilepsia 2010;51(11):2270–9. DOI: 10.1111/j.1528-1167.2010.02739.x.Striano S., Striano P. Clinical features and evolution of the gelastic seizures – hypothalamic hamartoma syndrome. Epilepsia 2017;58 Suppl 2:12–5. DOI: 10.1111/epi. 13753.Striano S., Striano P. Clinical features and evolution of the gelastic seizures – hypothalamic hamartoma syndrome. Epilepsia 2017;58 Suppl 2:12–5. DOI: 10.1111/epi. 13753.Oehl B., Brandt A., Fauser S. et al. Semiologic aspects of epileptic seizures in 31 patients with hypothalamic hamartoma. Epilepsia 2010;51(10):2116–23. DOI: 10.1111/j.1528-1167.2010.02686.x.Oehl B., Brandt A., Fauser S. et al. Semiologic aspects of epileptic seizures in 31 patients with hypothalamic hamartoma. Epilepsia 2010;51(10):2116–23. DOI: 10.1111/j.1528-1167.2010.02686.x.Blumberg J., Fernández I.S., Vendrame M. et al. Dacrystic seizures: demographic, semiologic, and etiologic insights from a multicenter study in long-term videoEEG monitoring units. Epilepsia 2012;53(10):1810–9. DOI: 10.1111/j.1528-1167.2012.03578.x.Blumberg J., Fernández I.S., Vendrame M. et al. Dacrystic seizures: demographic, semiologic, and etiologic insights from a multicenter study in long-term videoEEG monitoring units. Epilepsia 2012;53(10):1810–9. DOI: 10.1111/j.1528-1167.2012.03578.x.Berberoğlu M. Precocious puberty and normal variant puberty: definition, etiology, diagnosis and current management. J Clin Res Pediatr Endocrinol 2009;1(4):164–74. DOI: 10.4274/jcrpe.v1i4.3.Berberoğlu M. Precocious puberty and normal variant puberty: definition, etiology, diagnosis and current management. J Clin Res Pediatr Endocrinol 2009;1(4):164–74. DOI: 10.4274/jcrpe.v1i4.3.Chan Y.M., Fenoglio-Simeone K.A., Paraschos S. et al. Central precocious puberty due to hypothalamic hamartomas correlates with anatomic features but not with expression of GnRH, TGFalpha, or KISS1. Horm Res Paediatr 2010;73(5): 312–9. DOI: 10.1159/000308162.Chan Y.M., Fenoglio-Simeone K.A., Paraschos S. et al. Central precocious puberty due to hypothalamic hamartomas correlates with anatomic features but not with expression of GnRH, TGFalpha, or KISS1. Horm Res Paediatr 2010;73(5): 312–9. DOI: 10.1159/000308162.Mittal S., Mittal M., Montes J.L. et al. Hypothalamic hamartomas. Part 1. Clinical, neuroimaging, and neurophysiological characteristics. Neurosurg Focus 2013;34(6):E6. DOI: 10.3171/2013.3.FOCUS1355.Mittal S., Mittal M., Montes J.L. et al. Hypothalamic hamartomas. Part 1. Clinical, neuroimaging, and neurophysiological characteristics. Neurosurg Focus 2013;34(6):E6. DOI: 10.3171/2013.3.FOCUS1355.Kerrigan J.F., Ng Y.T., Chung S., Rekate H.L. The hypothalamic hamartoma: a model of subcortical epileptogenesis and encephalopathy. Semin Pediatr Neurol 2005;12(2):119–31.Kerrigan J.F., Ng Y.T., Chung S., Rekate H.L. The hypothalamic hamartoma: a model of subcortical epileptogenesis and encephalopathy. Semin Pediatr Neurol 2005;12(2):119–31.Striano S., Santulli L., Ianniciello M. et al. The gelastic seizures-hypothalamic hamartoma syndrome: facts, hypotheses, and perspectives. Epilepsy Behav 2012;24(1):7–13. DOI: 10.1016/j.yebeh.2012.02.013.Striano S., Santulli L., Ianniciello M. et al. The gelastic seizures-hypothalamic hamartoma syndrome: facts, hypotheses, and perspectives. Epilepsy Behav 2012;24(1):7–13. DOI: 10.1016/j.yebeh.2012.02.013.Freeman J.L., Coleman L.T., Wellard R.M. et al. MR imaging and spectroscopic study of epileptogenic hypothalamic hamartomas: analysis of 72 cases. ALNR Am J Neuroradiol 2004;25(3):450–62.Freeman J.L., Coleman L.T., Wellard R.M. et al. MR imaging and spectroscopic study of epileptogenic hypothalamic hamartomas: analysis of 72 cases. ALNR Am J Neuroradiol 2004;25(3):450–62.Kerrigan J.F., Parsons A., Tsang C. et al. Hypothalamic hamartoma: neuropathology and epileptogenesis. Epilepsia 2017;58 Suppl 2:22–31. DOI: 10.1111/epi.13752.Kerrigan J.F., Parsons A., Tsang C. et al. Hypothalamic hamartoma: neuropathology and epileptogenesis. Epilepsia 2017;58 Suppl 2:22–31. DOI: 10.1111/epi.13752.Kerrigan J.F., Parsons A., Rice S.G. et al. Hypothalamic hamartomas: neuropathological features with and without prior gamma knife radiosurgery. Stereotact Funct Neurosurg 2013;91(1):45–55. DOI: 10.1159/000341076.Kerrigan J.F., Parsons A., Rice S.G. et al. Hypothalamic hamartomas: neuropathological features with and without prior gamma knife radiosurgery. Stereotact Funct Neurosurg 2013;91(1):45–55. DOI: 10.1159/000341076.Leal A.J., Monteiro J.P., Secca M.F., Jordão C. Functional brain mapping of ictal activity in gelastic epilepsy associated with hypothalamic hamartoma: a case report. Epilepsia 2009;50(6):1624–31. DOI: 10.1111/j.15281167.2008.01810.x.Leal A.J., Monteiro J.P., Secca M.F., Jordão C. Functional brain mapping of ictal activity in gelastic epilepsy associated with hypothalamic hamartoma: a case report. Epilepsia 2009;50(6):1624–31. DOI: 10.1111/j.15281167.2008.01810.x.Hildebrand M.S., Griffin N.G., Damiano J.A. et al. Mutations of the sonic hedgehog pathway underlie hypothalamic hamartoma with gelastic epilepsy. Am J Hum Genet 2016;99(2):423–9. DOI: 10.1016/j.ajhg.2016.05.031.Hildebrand M.S., Griffin N.G., Damiano J.A. et al. Mutations of the sonic hedgehog pathway underlie hypothalamic hamartoma with gelastic epilepsy. Am J Hum Genet 2016;99(2):423–9. DOI: 10.1016/j.ajhg.2016.05.031.Palmini A., Chandler C., Andermann F. et al. Resection of the lesion in patients with hypothalamic hamartomas and catastrophic epilepsy. Neurology 2002;58(9):1338–47.Palmini A., Chandler C., Andermann F. et al. Resection of the lesion in patients with hypothalamic hamartomas and catastrophic epilepsy. Neurology 2002;58(9):1338–47.Ryvlin P., Ravier C., Bouvard S. et al. Positron emission tomography in epileptogenic hypothalamic hamartomas. Epileptic Dis 2003;5(4):219–27.Ryvlin P., Ravier C., Bouvard S. et al. Positron emission tomography in epileptogenic hypothalamic hamartomas. Epileptic Dis 2003;5(4):219–27.Palmini A., Van Paesschen W., Dupont P. et al. Status gelasticus after temporal lobectomy: ictal FDG‐PET findings and the question of dual pathology involving hypothalamic hamartomas. Epilepsia 2005;46(8):1313–6. DOI: 10.1111/j.15281167.2005.52804.x.Palmini A., Van Paesschen W., Dupont P. et al. Status gelasticus after temporal lobectomy: ictal FDG‐PET findings and the question of dual pathology involving hypothalamic hamartomas. Epilepsia 2005;46(8):1313–6. DOI: 10.1111/j.15281167.2005.52804.x.Shahar E., Goldsher D., Genizi J. et al. Intractable gelastic seizures during infancy: ictal positron emission tomography(PET) demonstrating epileptiform activity within the hypothalamic hamartoma. J Child Neurol 2008;23(2):235–9. DOI: 10.1177/0883073807308703.Shahar E., Goldsher D., Genizi J. et al. Intractable gelastic seizures during infancy: ictal positron emission tomography(PET) demonstrating epileptiform activity within the hypothalamic hamartoma. J Child Neurol 2008;23(2):235–9. DOI: 10.1177/0883073807308703.Wakamoto H., Sumi A., Motoki T., Ohmori H. Positron emission tomography with glucose hypermetabolism of a hypothalamic hamartoma in infantile spasms associated with Pallister–Hall syndrome. Brain Dev 2010;32(8):677–80. DOI: 10.1016/j.braindev.2009.09.003.Wakamoto H., Sumi A., Motoki T., Ohmori H. Positron emission tomography with glucose hypermetabolism of a hypothalamic hamartoma in infantile spasms associated with Pallister–Hall syndrome. Brain Dev 2010;32(8):677–80. DOI: 10.1016/j.braindev.2009.09.003.Arroyo S., Santamaría J., Sanmartí F. et al. Ictal laughter associated with paroxysmal hypothalamopituitary dysfunction. Epilepsia 1997;38(1):114–7.Arroyo S., Santamaría J., Sanmartí F. et al. Ictal laughter associated with paroxysmal hypothalamopituitary dysfunction. Epilepsia 1997;38(1):114–7.DiFazio M. P., Davis R.G. Utility of early single photon emission computed tomography (SPECT) in neonatal gelastic epilepsy associated with hypothalamic hamartoma. J Child Neurol 2000;15(6):414–7. DOI: 10.1177/088307380001500611.DiFazio M. P., Davis R.G. Utility of early single photon emission computed tomography (SPECT) in neonatal gelastic epilepsy associated with hypothalamic hamartoma. J Child Neurol 2000;15(6):414–7. DOI: 10.1177/088307380001500611.Dunoyer C., Ragheb J., Resnick T. et al. The use of stereotactic radiosurgery to treat intractable childhood partial epilepsy. Epilepsia 2002;43(3):292–300.Dunoyer C., Ragheb J., Resnick T. et al. The use of stereotactic radiosurgery to treat intractable childhood partial epilepsy. Epilepsia 2002;43(3):292–300.Coons S.W., Rekate H.L., Prenger E.C. et al. The histopathology of hypothalamic hamartomas: study of 57 cases. J Neuropathol Exp Neurol 2007;66(2):131–41. DOI: 10.1097/nen. 0b013e3180302090.Coons S.W., Rekate H.L., Prenger E.C. et al. The histopathology of hypothalamic hamartomas: study of 57 cases. J Neuropathol Exp Neurol 2007;66(2):131–41. DOI: 10.1097/nen. 0b013e3180302090.Wu J., Gao M., Shen J.X. et al. Mechanisms of intrinsic epileptogenesis in human gelastic seizures with hypothalamic hamartoma. CNS Neurosci Ther 2015; 21(2):104–11. DOI: 10.1111/cns.12348.Wu J., Gao M., Shen J.X. et al. Mechanisms of intrinsic epileptogenesis in human gelastic seizures with hypothalamic hamartoma. CNS Neurosci Ther 2015; 21(2):104–11. DOI: 10.1111/cns.12348.Troester M., Haine-Schlagel R., Ng Y.T. et al. EEG and video-EEG seizure monitoring has limited utility in patients with hypothalamic hamartoma and epilepsy. Epilepsia 2011;52(6):1137–43. DOI: 10.1111/j.1528-1167.2011.03095.x.Troester M., Haine-Schlagel R., Ng Y.T. et al. EEG and video-EEG seizure monitoring has limited utility in patients with hypothalamic hamartoma and epilepsy. Epilepsia 2011;52(6):1137–43. DOI: 10.1111/j.1528-1167.2011.03095.x.Munari C., Kahane P., Francione S. et al. Role of the hypothalamic hamartoma in the genesis of gelastic fits (a videostereo-EEG study). Electroencephalogr Clin Neurophysiol 1995;95(3):154–60.Munari C., Kahane P., Francione S. et al. Role of the hypothalamic hamartoma in the genesis of gelastic fits (a videostereo-EEG study). Electroencephalogr Clin Neurophysiol 1995;95(3):154–60.Kahane P., Ryvlin P., Hoffmann D. et al. From hypothalamic hamartoma to cortex: what can be learnt from depth recordings and stimulation? Epileptic Disord 2003;5(4):205–17.Kahane P., Ryvlin P., Hoffmann D. et al. From hypothalamic hamartoma to cortex: what can be learnt from depth recordings and stimulation? Epileptic Disord 2003;5(4):205–17.Morrell F. Secondary epileptogenesis in man. Arch Neurol 1985;42(4):318–35.Morrell F. Secondary epileptogenesis in man. Arch Neurol 1985;42(4):318–35.Goddard G.V. Development of epileptic seizures through brain stimulation at low intensity. Nature 1967;214(5092):1020–1.Goddard G.V. Development of epileptic seizures through brain stimulation at low intensity. Nature 1967;214(5092):1020–1.Morrell F., Roberts L., Jasper H.H. Effect of focal epileptogenic lesions and their ablation upon conditioned electrical responses of the brain in the monkey. Electroencephalogr Clin Neurophysiol 1956;8(2):217–36.Morrell F., Roberts L., Jasper H.H. Effect of focal epileptogenic lesions and their ablation upon conditioned electrical responses of the brain in the monkey. Electroencephalogr Clin Neurophysiol 1956;8(2):217–36.Scholly J., Staack A.M., Kahane P. et al. Hypothalamic hamartoma: Epileptogenesis beyond the lesion? Epilepsia 2017;58 Suppl 2:32–40. DOI: 10.1111/epi.13755.Scholly J., Staack A.M., Kahane P. et al. Hypothalamic hamartoma: Epileptogenesis beyond the lesion? Epilepsia 2017;58 Suppl 2:32–40. DOI: 10.1111/epi.13755.Cibula J.E., Gilmore R.L. Secondary epileptogenesis in humans. J Clin Neurophysiol 1997;14(2):111–27.Cibula J.E., Gilmore R.L. Secondary epileptogenesis in humans. J Clin Neurophysiol 1997;14(2):111–27.Steinmetz P.N., Wait S.D., Lekovic G.P. et al. Firing behavior and network activity of single neurons in human epileptic hypothalamic hamartoma. Front Neurol 2013;4:210. DOI: 10.3389/fneur.2013.00210.Steinmetz P.N., Wait S.D., Lekovic G.P. et al. Firing behavior and network activity of single neurons in human epileptic hypothalamic hamartoma. Front Neurol 2013;4:210. DOI: 10.3389/fneur.2013.00210.Marescaux C., Vergnes M., Kiesmann M. et al. Kindling of audiogenic seizures in Wistar rats: an EEG study. Exp Neurol 1987;97(1):160–8.Marescaux C., Vergnes M., Kiesmann M. et al. Kindling of audiogenic seizures in Wistar rats: an EEG study. Exp Neurol 1987;97(1):160–8.Hirsch E., Maton B., Vergnes M. et al. Positive transfer of audiogenic kindling to electrical hippocampal kindling in rats. Epilepsy Res 1992;11(3):159–66.Hirsch E., Maton B., Vergnes M. et al. Positive transfer of audiogenic kindling to electrical hippocampal kindling in rats. Epilepsy Res 1992;11(3):159–66.Valentin A., Lazaro M., Mullatti N. et al. Cingulate epileptogenesis in hypothalamic hamartoma. Epilepsia 2011;52(5):e35–9. DOI: 10.1111/j.1528–1167.2011.03060.x.Valentin A., Lazaro M., Mullatti N. et al. Cingulate epileptogenesis in hypothalamic hamartoma. Epilepsia 2011;52(5):e35–9. DOI: 10.1111/j.1528–1167.2011.03060.x.Arroyo S., Lesser R.P., Gordon B. et al. Mirth, laughter and gelastic seizures. Brain 1993;116(Pt 4):757–80.Arroyo S., Lesser R.P., Gordon B. et al. Mirth, laughter and gelastic seizures. Brain 1993;116(Pt 4):757–80.Scholly J., Valenti M.P., Staack A.M. et al. Hypothalamic hamartoma: is the epileptogenic zone always hypothalamic? Arguments for independent (third stage) secondary epileptogenesis. Epilepsia 2013;54 Suppl 9:123–8. DOI: 10.1111/epi.12456.Scholly J., Valenti M.P., Staack A.M. et al. Hypothalamic hamartoma: is the epileptogenic zone always hypothalamic? Arguments for independent (third stage) secondary epileptogenesis. Epilepsia 2013;54 Suppl 9:123–8. DOI: 10.1111/epi.12456.Northfield D.W., Russell D.S. Pubertas praecox due to hypothalamic hamartoma: report of two cases surviving surgical removal of the tumour. J Neurol Neurosurg Psychiatry 1967;30(2):166–73.Northfield D.W., Russell D.S. Pubertas praecox due to hypothalamic hamartoma: report of two cases surviving surgical removal of the tumour. J Neurol Neurosurg Psychiatry 1967;30(2):166–73.Paillas J.E., Roger J., Toga M. et al. [Hamartoma of the hypothalamus. Clinical, radiological and histological study. Results of excision(In French)]. Rev Neurol (Paris) 1969;120(3):177–94.Paillas J.E., Roger J., Toga M. et al. [Hamartoma of the hypothalamus. Clinical, radiological and histological study. Results of excision(In French)]. Rev Neurol (Paris) 1969;120(3):177–94.Cascino G.D., Andermann F., Berkovic S.F. et al. Gelastic seizures and hypothalamic hamartomas Evaluation of patients undergoing chronic intracranial EEG monitoring and outcome of surgical treatment. Neurology 1993;43(4):747–50.Cascino G.D., Andermann F., Berkovic S.F. et al. Gelastic seizures and hypothalamic hamartomas Evaluation of patients undergoing chronic intracranial EEG monitoring and outcome of surgical treatment. Neurology 1993;43(4):747–50.Kuzniecky R. Hypothalamic hamartomas and gelastic seizures: evidence for subcortical seizure generation by ictal SPECT and cerebral stimulation. Epilepsia 1995;36(3):S266.Kuzniecky R. Hypothalamic hamartomas and gelastic seizures: evidence for subcortical seizure generation by ictal SPECT and cerebral stimulation. Epilepsia 1995;36(3):S266.Berkovic S.F., Kuzniecky R.I., Andermann F. Human epileptogenesis and hypothalamic hamartomas: new lessons from an experiment of nature. Epilepsia 1997;38(1):1–3.Berkovic S.F., Kuzniecky R.I., Andermann F. Human epileptogenesis and hypothalamic hamartomas: new lessons from an experiment of nature. Epilepsia 1997;38(1):1–3.Berkovic S.F., Arzimanoglou A., Kuzniecky R. et al. Hypothalamic hamartoma and seizures: a treatable epileptic encephalopathy. Epilepsia 2003;44(7):969–73.Berkovic S.F., Arzimanoglou A., Kuzniecky R. et al. Hypothalamic hamartoma and seizures: a treatable epileptic encephalopathy. Epilepsia 2003;44(7):969–73.Freeman J.L., Harvey A.S., Rosenfeld J.V. et al. Generalized epilepsy in hypothalamic hamartoma evolution and postoperative resolution. Neurology 2003;60(5):762–7.Freeman J.L., Harvey A.S., Rosenfeld J.V. et al. Generalized epilepsy in hypothalamic hamartoma evolution and postoperative resolution. Neurology 2003;60(5):762–7.Andermann F., Arzimanoglou A., Berkovic S.F. Hypothalamic hamartoma and epilepsy: the pathway of discovery. Epileptic Dis 2003;5(4):173–5.Andermann F., Arzimanoglou A., Berkovic S.F. Hypothalamic hamartoma and epilepsy: the pathway of discovery. Epileptic Dis 2003;5(4):173–5.Rosenfeld J.V., Harvey A.S., Wrennall J. et al. Transcallosal resection of hypothalamic hamartomas, with control ofseizures, in children with gelastic epilepsy. Neurosurgery 2001;48(1):108–18.Rosenfeld J.V., Harvey A.S., Wrennall J. et al. Transcallosal resection of hypothalamic hamartomas, with control ofseizures, in children with gelastic epilepsy. Neurosurgery 2001;48(1):108–18.Rekate H.L., Feiz-Erfan I., Ng Y.T. et al. Endoscopic surgery for hypothalamic hamartomas causing medically refractory gelastic epilepsy. Childs Nerv Syst 2006;22(8):874–80. DOI: 10.1007/s00381-006-0125-4.Rekate H.L., Feiz-Erfan I., Ng Y.T. et al. Endoscopic surgery for hypothalamic hamartomas causing medically refractory gelastic epilepsy. Childs Nerv Syst 2006;22(8):874–80. DOI: 10.1007/s00381-006-0125-4.Parrent A.G. Stereotactic radiofrequency ablation for the treatment of gelastic seizures associated with hypothalamic hamartoma: case report. J Neurosurg 1999;91(5):881–4. DOI: 10.3171/jns.1999.91.5.0881.Parrent A.G. Stereotactic radiofrequency ablation for the treatment of gelastic seizures associated with hypothalamic hamartoma: case report. J Neurosurg 1999;91(5):881–4. DOI: 10.3171/jns.1999.91.5.0881.Schulze-Bonhage A., Homberg V., Trippel M. et al. Interstitial radiosurgery in the treatment of gelastic epilepsy due to hypothalamic hamartomas. Neurology 2004;62(4):644–7.Schulze-Bonhage A., Homberg V., Trippel M. et al. Interstitial radiosurgery in the treatment of gelastic epilepsy due to hypothalamic hamartomas. Neurology 2004;62(4):644–7.Régis J., Bartolomei F., de Toffol B. et al. Gamma knife surgery for epilepsy related to hypothalamic hamartomas. Neurosurgery 2000;47(6):1343–51.Régis J., Bartolomei F., de Toffol B. et al. Gamma knife surgery for epilepsy related to hypothalamic hamartomas. Neurosurgery 2000;47(6):1343–51.Freeman J.L., Zacharin M., Rosenfeld J.V., Harvey A.S. The endocrinology of hypothalamic hamartoma surgery for intractable epilepsy. Epileptic Disord 2003;5(4):239–47.Freeman J.L., Zacharin M., Rosenfeld J.V., Harvey A.S. The endocrinology of hypothalamic hamartoma surgery for intractable epilepsy. Epileptic Disord 2003;5(4):239–47.Régis J., Scavarda D., Tamura M. et al. Epilepsy related to hypothalamic hamartomas: surgical management with special reference to gamma knife surgery. Childs Nerv Syst 2006;22(8):881–95. DOI: 10.1007/s00381-006-0139-y.Régis J., Scavarda D., Tamura M. et al. Epilepsy related to hypothalamic hamartomas: surgical management with special reference to gamma knife surgery. Childs Nerv Syst 2006;22(8):881–95. DOI: 10.1007/s00381-006-0139-y.Schulze-Bonhage A., Trippel M., Wagner K. et al. Outcome and predictors of interstitial radiosurgery in the treatment of gelastic epilepsy. Neurology 2008;71(4):277–82. DOI: 10.1212/01.wnl.0000318279.92233.82.Schulze-Bonhage A., Trippel M., Wagner K. et al. Outcome and predictors of interstitial radiosurgery in the treatment of gelastic epilepsy. Neurology 2008;71(4):277–82. DOI: 10.1212/01.wnl.0000318279.92233.82.Castinetti F., Brue T., Morange I. et al. Gamma Knife radiosurgery for hypothalamic hamartoma preserves endocrine functions. Epilepsia 2017;58 Suppl 2:72–6. DOI: 10.1111/epi.13760.Castinetti F., Brue T., Morange I. et al. Gamma Knife radiosurgery for hypothalamic hamartoma preserves endocrine functions. Epilepsia 2017;58 Suppl 2:72–6. DOI: 10.1111/epi.13760.Anderson J.F., Rosenfeld J.V. Long-term cognitive outcome after transcallosal resection of hypothalamic hamartoma in older adolescents and adults with gelastic seizures. Epilepsy Behav 2010;18(1–2): 81–7. DOI: 10.1016/j.yebeh.2010.02.018.Anderson J.F., Rosenfeld J.V. Long-term cognitive outcome after transcallosal resection of hypothalamic hamartoma in older adolescents and adults with gelastic seizures. Epilepsy Behav 2010;18(1–2): 81–7. DOI: 10.1016/j.yebeh.2010.02.018.Ng Y.T., Rekate H.L., Prenger E.C. et al. Endoscopic resection of hypothalamic hamartomas for refractory symptomatic epilepsy. Neurology 2008;70(17):1543–8. DOI: 10.1212/01.wnl.0000310644.40767.aa.Ng Y.T., Rekate H.L., Prenger E.C. et al. Endoscopic resection of hypothalamic hamartomas for refractory symptomatic epilepsy. Neurology 2008;70(17):1543–8. DOI: 10.1212/01.wnl.0000310644.40767.aa.Wagner K., Buschmann F., Zentner J. et al. Memory outcome one year after stereotactic interstitial radiosurgery in patients with epilepsy due to hypothalamic hamartomas. Epilepsy Behav 2014;37:204–9. DOI: 10.1016/j.yebeh.2014.06.031.Wagner K., Buschmann F., Zentner J. et al. Memory outcome one year after stereotactic interstitial radiosurgery in patients with epilepsy due to hypothalamic hamartomas. Epilepsy Behav 2014;37:204–9. DOI: 10.1016/j.yebeh.2014.06.031.Голанов А.В., Корниенко В.Н., Трунин Ю.Ю. и др. Стереотаксическая радиохирургия в лечении пациентов с гамартомами гипоталамуса. Журнал «Вопросы нейрохирургии им. Н.Н. Бурденко» 2010;(1):24–9. [Golanov A.V., Kornienko V.N., Trunin Yu.Yu. et al. Stereotactic radiosurgery in treatment of patients with hypothalamic hamartomas. Zhurnal “Voprosy neirokhirurgii im. N.N. Burdenko” = Problems of Neurosurgery n. a. N.N. Burdenko 2010;(1):24–9. (In Russ.)].Голанов А.В., Корниенко В.Н., Трунин Ю.Ю. и др. Стереотаксическая радиохирургия в лечении пациентов с гамартомами гипоталамуса. Журнал «Вопросы нейрохирургии им. Н.Н. Бурденко» 2010;(1):24–9. [Golanov A.V., Kornienko V.N., Trunin Yu.Yu. et al. Stereotactic radiosurgery in treatment of patients with hypothalamic hamartomas. Zhurnal “Voprosy neirokhirurgii im. N.N. Burdenko” = Problems of Neurosurgery n. a. N.N. Burdenko 2010;(1):24–9. (In Russ.)].Burrows A.M., Marsh W.R., Worrell G. et al. Magnetic resonance imaging-guided laser interstitial thermal therapy for previously treated hypothalamic hamartomas. Neurosurg Focus 2016;41(4):E8. DOI: 10.3171/2016.7.FOCUS16218.Burrows A.M., Marsh W.R., Worrell G. et al. Magnetic resonance imaging-guided laser interstitial thermal therapy for previously treated hypothalamic hamartomas. Neurosurg Focus 2016;41(4):E8. DOI: 10.3171/2016.7.FOCUS16218.Du V.X., Gandhi S.V., Rekate H.L., Mehta A.D. Laser interstitial thermal therapy: a first line treatment for seizures due to hypothalamic hamartoma? Epilepsia 2017;58 Suppl 2:77–84. DOI: 10.1111/epi.13751.Du V.X., Gandhi S.V., Rekate H.L., Mehta A.D. Laser interstitial thermal therapy: a first line treatment for seizures due to hypothalamic hamartoma? Epilepsia 2017;58 Suppl 2:77–84. DOI: 10.1111/epi.13751.Григорьев А.Ю., Трифонов И.С., Синкин М.В. и др. Трансназальное эндоскопическое удаление гипоталамической гамартомы (наблюдения из практики). Нейрохирургия 2019;21(1):72–82. [Grigoriev А.Yu., Trifonov I.S., Sinkin М.V. et al. Transnasal endoscopic removal of hypothalamic hamartoma(case reports). Neyrokhirurgiya = Russian Journal of Neurosurgery 2019;21(1):72–82. (In Russ.)].Григорьев А.Ю., Трифонов И.С., Синкин М.В. и др. Трансназальное эндоскопическое удаление гипоталамической гамартомы (наблюдения из практики). Нейрохирургия 2019;21(1):72–82. [Grigoriev А.Yu., Trifonov I.S., Sinkin М.V. et al. Transnasal endoscopic removal of hypothalamic hamartoma(case reports). Neyrokhirurgiya = Russian Journal of Neurosurgery 2019;21(1):72–82. (In Russ.)].Harvey A.S., Freeman J.L., Berkovic S.F., Rosenfeld J.V. Transcallosal resection of hypothalamic hamartomas in patients with intractable epilepsy. Epileptic Disord 2003;5(4):257–65.Harvey A.S., Freeman J.L., Berkovic S.F., Rosenfeld J.V. Transcallosal resection of hypothalamic hamartomas in patients with intractable epilepsy. Epileptic Disord 2003;5(4):257–65.Ng Y., Rekate H.L., Prenger E.C. et al. Transcallosal resection of hypothalamic hamartoma for intractable epilepsy. Epilepsia 2006;47(7):1192–202. DOI: 10.1111/j.1528-1167.2006.00516.x.Ng Y., Rekate H.L., Prenger E.C. et al. Transcallosal resection of hypothalamic hamartoma for intractable epilepsy. Epilepsia 2006;47(7):1192–202. DOI: 10.1111/j.1528-1167.2006.00516.x.Procaccini E., Dorfmüller G., Fohlen M. et al. Surgical management of hypothalamic hamartomas with epilepsy: the stereoendoscopic approach. Neurosurgery 2006;59(4 Suppl 2):ONS-336–44. DOI: 10.1227/01.NEU.0000233900.06146.72.Procaccini E., Dorfmüller G., Fohlen M. et al. Surgical management of hypothalamic hamartomas with epilepsy: the stereoendoscopic approach. Neurosurgery 2006;59(4 Suppl 2):ONS-336–44. DOI: 10.1227/01.NEU.0000233900.06146.72.Wilfong A.A., Curry D.J. Hypothalamic hamartomas: optimal approach to clinical evaluation and diagnosis. Epilepsia 2013; Suppl 9:109–14. DOI: 10.1111/epi.12454.Wilfong A.A., Curry D.J. Hypothalamic hamartomas: optimal approach to clinical evaluation and diagnosis. Epilepsia 2013; Suppl 9:109–14. DOI: 10.1111/epi.12454.Calisto A., Dorfmüller G., Fohlen M. et al. Endoscopic disconnection of hypothalamic hamartomas: safety and feasibility of robot-assisted, thulium laserbased procedures. J Neurosurg Pediatr 2014;14(6):563–72. DOI: 10.3171/2014.8.PEDS13586.Calisto A., Dorfmüller G., Fohlen M. et al. Endoscopic disconnection of hypothalamic hamartomas: safety and feasibility of robot-assisted, thulium laserbased procedures. J Neurosurg Pediatr 2014;14(6):563–72. DOI: 10.3171/2014.8.PEDS13586.Kameyama S., Shirozu H., Masuda H. et al. MRI-guided stereotactic radiofrequency thermocoagulation for 100 hypothalamic hamartomas. J Neurosurg 2016;124(5):1503–12. DOI: 10.3171/2015.4.JNS1582.Kameyama S., Shirozu H., Masuda H. et al. MRI-guided stereotactic radiofrequency thermocoagulation for 100 hypothalamic hamartomas. J Neurosurg 2016;124(5):1503–12. DOI: 10.3171/2015.4.JNS1582.Régis J., Lagmari M., Carron R. et al. Safety and efficacy of Gamma Knife radiosurgery in hypothalamic hamartomas with severe epilepsies: a prospective trial in 48 patients and review of the literature. Epilepsia 2017;58 Suppl 2:60–71. DOI: 10.1111/epi.13754.Régis J., Lagmari M., Carron R. et al. Safety and efficacy of Gamma Knife radiosurgery in hypothalamic hamartomas with severe epilepsies: a prospective trial in 48 patients and review of the literature. Epilepsia 2017;58 Suppl 2:60–71. DOI: 10.1111/epi.13754.Xu D.S., Chen T., Hlubek R.J. et al. Magnetic resonance imaging-guided laser interstitial thermal therapy for the treatment of hypothalamic hamartomas: a retrospective review. Neurosurgery 2018;83(6):1183–92. DOI: 10.1093/neuros/nyx604.Xu D.S., Chen T., Hlubek R.J. et al. Magnetic resonance imaging-guided laser interstitial thermal therapy for the treatment of hypothalamic hamartomas: a retrospective review. Neurosurgery 2018;83(6):1183–92. DOI: 10.1093/neuros/nyx604.Curry D.J., Raskin J., Ali I., Wilfong A.A. MR-guided laser ablation for the treatment of hypothalamic hamartomas. Epilepsy Res 2018;142:131–4. DOI: 10.1016/j.eplepsyres.2018.03.013.Curry D.J., Raskin J., Ali I., Wilfong A.A. MR-guided laser ablation for the treatment of hypothalamic hamartomas. Epilepsy Res 2018;142:131–4. DOI: 10.1016/j.eplepsyres.2018.03.013.

The authors declare that there are no conflicts of interest present.