neurosurgeryНейрохирургияRussian journal of neurosurgery1683-32952587-7569Издательский дом "МедИНК"10.17650/1683-3295-2019-21-2-76-84neurosurgery-722Research ArticleОБЗОРЫ ЛИТЕРАТУРЫLITERATURE REVIEWХИРУРГИЧЕСКОЕ ЛЕЧЕНИЕ МРТ-НЕГАТИВНОЙ ВИСОЧНОЙ ЭПИЛЕПСИИ (ОБЗОР ЛИТЕРАТУРЫ)SURGICAL TREATMENT OF MRI-NEGATIVE EPILEPSY (A REVIEW)https://orcid.org/0000-0002-6911-0975ТрифоновИ. С.TrifonovI. S.https://orcid.org/0000-0003-0432-2915КордонскаяО. О.KordonskayaO. O.dr.kordonskaya@gmail.comhttps://orcid.org/0000-0001-5026-0060СинкинМ. В.SinkinM. V.

127473 Москва, ул. Делегатская, 20, стр. 1;

129090 Москва, Большая Сухаревская пл., 3

Bld. 1, 20 Delegatskaya St., Moscow 127473;

3 Bol’shaya Sukharevskaya Sq., Moscow 129090 

https://orcid.org/0000-0001-8207-7180ГригорьеваЕ. В.GrigorievaE. V.

127473 Москва, ул. Делегатская, 20, стр. 1

Bld. 1, 20 Delegatskaya St., Moscow 127473

ФГБОУ ВО «Московский государственный медико-стоматологический университет им. А.И. Евдокимова» Минздрава РоссииРоссияA.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of RussiaRussian FederationГБУЗ «Научно-исследовательский институт скорой помощи им. Н.В. Склифосовского Департамента здравоохранения г. Москвы»РоссияN.V. Sklifosovsky Research Institute for Emergency Medicine, Moscow Healthcare DepartmentRussian FederationФГБОУ ВО «Московский государственный медико-стоматологический университет им. А.И. Евдокимова» Минздрава России; ГБУЗ «Научно-исследовательский институт скорой помощи им. Н.В. Склифосовского Департамента здравоохранения г. Москвы»РоссияA.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia; N.V. Sklifosovsky Research Institute for Emergency Medicine, Moscow Healthcare DepartmentRussian Federation2019160620192127684Copyright © Трифонов И.С., Кордонская О.О., Синкин М.В., Григорьева Е.В., 20192019Трифонов И.С., Кордонская О.О., Синкин М.В., Григорьева Е.В.Trifonov I.S., Kordonskaya O.O., Sinkin M.V., Grigorieva E.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.therjn.com/jour/article/view/722

Резекция очага эпилептогенного поражения – эффективный и безопасный способ лечения пациентов с фармакорезистентной эпилепсией. Результат хирургического лечения зависит от правильного выявления зоны поражения, точного определения ее границ. Отсутствие патологии по данным магнитно-резонансной томографии головного мозга по «эпилептическому» протоколу не является противопоказанием к хирургическому лечению, но требует дополнительного обследования пациентов. Каждый из дополнительных методов имеет свои преимущества и недостатки. Комплексное обследование, тщательный анализ и сопоставление данных позитронной эмиссионной томографии, однофотонной эмиссионной компьютерной томографии, магнитной энцефалографии, скальповой и инвазивной продленной электроэнцефалографии позволяют существенно улучшить результаты хирургического лечения МРТ-негативной эпилепсии, а уточнение алгоритма предоперационной подготовки пациентов – оптимизировать применение того или иного диагностического метода.

Removal of epileptogenic lesions is an effective way to treat patients with drug-resistant epilepsy. The result of surgical treatment depends on the correct detection of pathology, definition of its boundaries. No lesion on magnetic resonance imaging is not a contraindication to surgical treatment, but requires a survey. Each of the additional methods has its advantages and disadvantages. Сomprehensive examination, analysis and comparison of positron emission tomography, single-photon emission computed tomography, magnetoencephalography, scalp and invasive electroencephalography data can significantly improve the results of surgical treatment MRI-negative epilepsy patients. Clarification of the pre-surgical evaluation algorithm will allow to optimize the use of techniques.

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The authors declare that there are no conflicts of interest present.