References

neurosurgery

Нейрохирургия

Russian journal of neurosurgery

1683-32952587-7569

Издательский дом "МедИНК"

10.17650/1683-3295-2019-21-2-66-75

neurosurgery-721

Research Article

ОБЗОРЫ ЛИТЕРАТУРЫ

LITERATURE REVIEW

РЕГЕНЕРАТИВНЫЕ МЕТОДЫ ЛЕЧЕНИЯ ТРАВМЫ СПИННОГО МОЗГА. ОБЗОР ЛИТЕРАТУРЫ. ЧАСТЬ 1

REGENERATIVE TREATMENT OF SPINAL CORD INJURY. LITERATURE REVIEW. PART 1

https://orcid.org/0000-0003-4096-1087

Смирнов

В. А.

Smirnov

V. А.

vla_smirnov@mail.ru

https://orcid.org/0000-0003-3515-8329

Гринь

А. А.

Grin

А. А.

129090 Москва, Большая Сухаревская пл., 3;

127473 Москва, ул. Делегатская, 20, стр. 1

3 Bol’shaya Sukharevskaya Sq., Moscow 129090;

Bld. 1, 20 Delegatskaya St., Moscow 127473

Крылов

В. В.

Krylov

V. V.

129090 Москва, Большая Сухаревская пл., 3;

127473 Москва, ул. Делегатская, 20, стр. 1

3 Bol’shaya Sukharevskaya Sq., Moscow 129090;

Bld. 1, 20 Delegatskaya St., Moscow 127473

ГБУЗ «Научно-исследовательский институт скорой помощи им. Н.В. Склифосовского Департамента здравоохранения г. Москвы»РоссияN.V. Sklifosovsky Research Institute for Emergency Medicine, Moscow Healthcare DepartmentRussian Federation

ГБУЗ «Научно-исследовательский институт скорой помощи им. Н.В. Склифосовского Департамента здравоохранения г. Москвы»; ФГБОУ ВО «Московский государственный медико-стоматологический университет им. А.И. Евдокимова» Минздрава РоссииРоссияN.V. Sklifosovsky Research Institute for Emergency Medicine, Moscow Healthcare Department; A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of RussiaRussian Federation

2019

16062019

2126675

2019

Смирнов В.А., Гринь А.А., Крылов В.В.

Smirnov V.А., Grin А.А., Krylov V.V.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.therjn.com/jour/article/view/721

Проблема лечения травматических повреждений спинного мозга – одна из наиболее сложных и актуальных в современной медицине. В подавляющем большинстве случаев травма спинного мозга (ТСМ) приводит к стойкой инвалидизации пациентов, что имеет как медико-социальные, так и экономические последствия для пациента, его семьи и государства. Современные методы лечения ТСМ обладают крайне ограниченной эффективностью и не позволяют в достаточной степени восстановить утраченные функции центральной нервной системы. Регенеративные методы и, в частности, клеточная терапия – очень многообещающее направление, дающее надежду на эффективное лечение ТСМ. В обзоре освещены проблемы эпидемиологии и патогенеза ТСМ, описаны существующие методы терапии, а также перспективные методы регенеративной терапии. Особое внимание уделено результатам доклинических и клинических исследований в области клеточной терапии. Обзор разделен на 4 части. В 1-й части освещаются эпидемиология и патогенез ТСМ, а также хирургические, физические, фармакологические методы ее лечения.

Treating traumatic spinal cord injuries is one of the most complicated and relevant problems in the modern medicine. In the vast majority of cases spinal cord injury (SCI) leads to persistent disability, with medical, social and economic consequences ensuing for the patient, the family and the state. Modern SCI therapy has a very limited effectiveness and does not allow to sufficiently restore the lost functions of central nervous system. Regenerative methods and particularly cell therapy are very promising to effectively treat SCI. The review highlights SCI epidemiological and pathogenetic problems, existing therapy, as well as promising methods of regenerative therapy. We emphasize the results of preclinical and clinical studies in the field of cell therapy. The review is divided into 4 parts. Part 1 describes SCI epidemiology and pathogenesis as well as its surgical, physical and pharmacological treatment.

травма спинного мозгаклеточная терапиярегенеративная терапияклетки пуповинной крови

spinal cord injurycell therapyregenerative therapycord blood cells

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The authors declare that there are no conflicts of interest present.