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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">neurosurgery</journal-id><journal-title-group><journal-title xml:lang="ru">Нейрохирургия</journal-title><trans-title-group xml:lang="en"><trans-title>Russian journal of neurosurgery</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1683-3295</issn><issn pub-type="epub">2587-7569</issn><publisher><publisher-name>Издательский дом "МедИНК"</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.17650/1683-3295-2018-20-4-68-74</article-id><article-id custom-type="elpub" pub-id-type="custom">neurosurgery-656</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>НАБЛЮДЕНИЕ ИЗ ПРАКТИКИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>FROM PRACTICE</subject></subj-group></article-categories><title-group><article-title>Лечение беременной с глиобластомой, осложненной острой окклюзионной гидроцефалией в стадии субкомпенсации (случай из практики)</article-title><trans-title-group xml:lang="en"><trans-title>Treatment of a pregnant woman with glioblastoma complicated by acute occlusive hydrocephalus in the subcompensation stage (from practice)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Крылов</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Krylov</surname><given-names>V. V.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"/><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8651-9986</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Годков</surname><given-names>И. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Godkov</surname><given-names>I. М.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"/><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3515-8329</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гринь</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Grin’</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Андрей Анатольевич Гринь </p><p>129090 Москва, Большая Сухаревская пл., 3; 127473 Москва, ул. Делегатская, 20, стр. 1</p><p> </p></bio><bio xml:lang="en"/><email xlink:type="simple">aagreen@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Нефедова</surname><given-names>Г. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Nefedova</surname><given-names>G. А.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"/><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ким</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Кim</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"/><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ГБУЗ «Научно-исследовательский институт скорой помощи им. Н.В. Склифосовского Департамента  здравоохранения г. Москвы»; &#13;
ФГБОУ ВО «Московский государственный медико-стоматологический университет им. А.И. Евдокимова» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>N. V. Sklifosovsky Research Institute for Emergency Medicine, Moscow Healthcare Department; &#13;
A. I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ГБУЗ «Научно-исследовательский институт скорой помощи им. Н.В. Склифосовского Департамента  здравоохранения г. Москвы»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>N. V. Sklifosovsky Research Institute for Emergency Medicine, Moscow Healthcare Department</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ГБУЗ «Городская клиническая больница им. В.П. Демихова Департамента здравоохранения г. Москвы»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>V.P. Demikhov City Hospital, Moscow Health Department</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>12</day><month>01</month><year>2019</year></pub-date><volume>20</volume><issue>4</issue><fpage>68</fpage><lpage>74</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Крылов В.В., Годков И.М., Гринь А.А., Нефедова Г.А., Ким А.В., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Крылов В.В., Годков И.М., Гринь А.А., Нефедова Г.А., Ким А.В.</copyright-holder><copyright-holder xml:lang="en">Krylov V.V., Godkov I.М., Grin’ A.A., Nefedova G.А., Кim A.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.therjn.com/jour/article/view/656">https://www.therjn.com/jour/article/view/656</self-uri><abstract><p>Цель исследования – представить редкое клиническое наблюдение, описать успешное 2-этапное нейрохирургическое лечение беременной пациентки с глиобластомой, осложненной острой окклюзионной гидроцефалией.</p><sec><title>Материалы и методы</title><p>Материалы и методы. Беременная, 36 лет (срок беременности 28–29 нед), госпитализирована по экстренным показаниям с подозрением на преэклампсию в многопрофильный стационар с роддомом. За 1 день до госпитализации у больной развился гипертензионный синдром, проявлявшийся головной болью, тошнотой, рвотой, угнетением сознания до оглушения, затем судорогами в конечностях с утратой сознания. В ходе обследования выявлена злокачественная паравентрикулярная опухоль левой височной и теменной долей, сопровождавшаяся перифокальным отеком, дислокацией мозга и острой тривентрикулярной окклюзионной гидроцефалией.</p></sec><sec><title>Результаты</title><p>Результаты. Лечение включало следующие этапы: 1) эндоскопическую тривентрикулоцистерностомию под местной анестезией в экстренном порядке, 2) досрочное родоразрешение путем кесарева сечения, 3) микрохирургическое удаление опухоли головного мозга. По результатам гистологического исследования диагностирована глиобластома (grade IV). Пациентка выписана с минимальным неврологическим дефицитом (элементами сенсомоторной афазии) для проведения химиолучевой терапии.</p></sec><sec><title>Заключение</title><p>Заключение. Хирургическое лечение пациентки с глиобластомой и остро развившейся окклюзионной гидроцефалией в III триместре беременности можно провести в 2 этапа эффективно и безопасно для матери и плода. Из ликворошунтирующих операций предпочтительна эндоскопическая тривентрикулостомия под местной анестезией.</p></sec></abstract><trans-abstract xml:lang="en"><p>The study objective is to present a rare clinical observation, describe a successful 2-stage neurosurgical treatment of a pregnant patient with glioblastoma complicated by acute occlusive hydrocephalus.</p><sec><title>Materials and methods</title><p>Materials and methods. A pregnant woman, 36 years (pregnancy 28–29 weeks), was urgently hospitalized with a suspicion for preeclampsia at a multispecialty hospital with a maternity ward. One day prior to hospitalization the patient developed hypertensive syndrome manifesting through headache, nausea, vomiting, depressed consciousness to stupor, then seizures in the extremities with loss of consciousness. Examination had shown malignant paraventricular tumor of the left temporal and parietal lobes accompanied by perifocal edema, brain dislocation, and acute occlusive triventricular hydrocephalus.</p></sec><sec><title>Results</title><p>Results. Treatment included the following stages: 1) emergency endoscopic third ventriculocisternostomy under local anesthesia, 2) premature delivery per cesarean section, 3) microsurgical resection of the brain tumor. Histological examination diagnosed glioblastoma (grade IV). The patient was discharged with minimal neurological deficiency (elements of motor and sensory aphasia) for administration of chemoradiation therapy.</p></sec><sec><title>Conclusion</title><p>Conclusion. Surgical treatment of a patient with glioblastoma and acute occlusive hydrocephalus in the 3rd trimester can be performed safely and effectively for the mother and fetus in 2 stages. Third ventriculocisternostomy under local anesthesia is recommended as a method of cerebrospinal fluid drainage.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>глиобластома</kwd><kwd>острая окклюзионная гидроцефалия</kwd><kwd>беременность</kwd><kwd>тривентрикулоцистерностомия</kwd><kwd>ликворошунтирующие операции</kwd></kwd-group><kwd-group xml:lang="en"><kwd>glioblastoma</kwd><kwd>acute occlusive hydrocephalus</kwd><kwd>pregnancy</kwd><kwd>third ventriculocisternostomy</kwd><kwd>cerebrospinal fluid drainage</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Khalid M.H., Shibata S., Furukawa K. et al. Role of estrogen receptor-related antigen in initiating the growth of human glioma cells. J Neurosurg 2004;100(5): 923–30. DOI: 10.3171/jns.2004.100.5.0923. PMID: 15137610.</mixed-citation><mixed-citation xml:lang="en">Khalid M.H., Shibata S., Furukawa K. et al. 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