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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">neurosurgery</journal-id><journal-title-group><journal-title xml:lang="ru">Нейрохирургия</journal-title><trans-title-group xml:lang="en"><trans-title>Russian journal of neurosurgery</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1683-3295</issn><issn pub-type="epub">2587-7569</issn><publisher><publisher-name>Издательский дом "МедИНК"</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">neurosurgery-592</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ ЛИТЕРАТУРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>LITERATURE REVIEW</subject></subj-group></article-categories><title-group><article-title>Первичная лимфома центральной нервной системы: клиника , диагностика , современные подходы к лечению</article-title><trans-title-group xml:lang="en"><trans-title></trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бублиевский</surname><given-names>Д.В.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Евзиков</surname><given-names>Г.Ю.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>Клиника нервных болезней ПМГМУ им. И.М. Сеченова</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2012</year></pub-date><pub-date pub-type="epub"><day>31</day><month>03</month><year>2012</year></pub-date><volume>12</volume><issue>1</issue><fpage>74</fpage><lpage>81</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Бублиевский Д., Евзиков Г., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Бублиевский Д., Евзиков Г.</copyright-holder><copyright-holder xml:lang="en">Бублиевский Д., Евзиков Г.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.therjn.com/jour/article/view/592">https://www.therjn.com/jour/article/view/592</self-uri><abstract><p>В связи с ростом числа выявляемости первичной лимфомы центральной нервной системы (ПЛ ЦНС) у людей среднего и пожилого возраста в настоящее время достаточно остро стоит проблема своевременной диагностики и адекватного лечения данного заболевания. Настоящая статья представляет собой сжатый обзор проблемы диагностики и сравнительной оценки эффективности методов лечения ПЛЦНС. Представлены основные гистологические формы лимфомы, локализация опухолевого поражения и нейровизуализационные характеристики, особенности применения хирургии, лучевой и химиотерапии.</p><sec><title> </title><p> </p></sec><sec><title> </title><p> </p></sec></abstract><trans-abstract xml:lang="en"><p>Nowadays the problem of on-time diagnosis and adequate treatment of primary central nervous system lymphoma is one of the top medical questions due to constantly increasing cases of this disease among people of middle and elderly age. This article presents the brief review of diagnosis problems and comparative estimation of efficacy of current methods for PL CNS treatment. The main histological types of lymphoma, tumor localizations, neurovisualization features as well as aspects of surgical, radiation and chemotherapy treatment modalities are enlighted in this written work.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>В-клеточная лимфома</kwd><kwd>ВААРТ</kwd><kwd>солитарный</kwd><kwd>множественный</kwd><kwd>биопсия</kwd><kwd>метотрексат</kwd><kwd>темозоламид</kwd><kwd>полихимиотерапия</kwd><kwd>гематоэнцефалический барьер.</kwd></kwd-group><kwd-group xml:lang="en"><kwd>cell lymphoma</kwd><kwd>HAART</kwd><kwd>solitary</kwd><kwd>multiple</kwd><kwd>biopsy</kwd><kwd>methotrexate</kwd><kwd>temozolomoide</kwd><kwd>polychemotherapy</kwd><kwd>blood-brain barrier</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Богданов А.Н., Максимов А.Г., Саржевский В.О., Аносов Н.А. Особые формы неходжкинских лимфом. 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