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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">neurosurgery</journal-id><journal-title-group><journal-title xml:lang="ru">Нейрохирургия</journal-title><trans-title-group xml:lang="en"><trans-title>Russian journal of neurosurgery</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1683-3295</issn><issn pub-type="epub">2587-7569</issn><publisher><publisher-name>Издательский дом "МедИНК"</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">neurosurgery-55</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНАЯ РАБОТА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL REPORT</subject></subj-group></article-categories><title-group><article-title>Моделирование гемодинамических изменений в артериях и артериальных аневризмах головного мозга при сосудистом спазме</article-title><trans-title-group xml:lang="en"><trans-title>The modeling of hemodynamic changes in cerebral arteries and cerebral aneurysms under condition of cerebral angiospasm</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Крылов</surname><given-names>Владимир Викторович</given-names></name><name name-style="western" xml:lang="en"><surname>Krylov</surname><given-names>V. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Природов</surname><given-names>Александр Владиславович</given-names></name><name name-style="western" xml:lang="en"><surname>Prirodov</surname><given-names>A. V.</given-names></name></name-alternatives><email xlink:type="simple">aprirodov@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Архипов</surname><given-names>Иван Владимирович</given-names></name><name name-style="western" xml:lang="en"><surname>Arkhipov</surname><given-names>I. V.</given-names></name></name-alternatives><email xlink:type="simple">arkhivania@gmail.com</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гаврилов</surname><given-names>Андрей Васильевич</given-names></name><name name-style="western" xml:lang="en"><surname>Gavrilov</surname><given-names>A. V.</given-names></name></name-alternatives><email xlink:type="simple">gavrilov@multivox.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Григорьева</surname><given-names>Елена Владимировна</given-names></name><name name-style="western" xml:lang="en"><surname>Grigorieva</surname><given-names>E. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ганин</surname><given-names>Геннадий Васильевич</given-names></name><name name-style="western" xml:lang="en"><surname>Ganin</surname><given-names>G. V.</given-names></name></name-alternatives><email xlink:type="simple">ganingv@mail.ru</email><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ятченко</surname><given-names>Артем Михайлович</given-names></name><name name-style="western" xml:lang="en"><surname>Iatchenko</surname><given-names>A. M.</given-names></name></name-alternatives><email xlink:type="simple">artem@yatchenko.com.ua</email><xref ref-type="aff" rid="aff-5"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>НИИ СП им. Н.В. Склифосовского</institution><country>Russian Federation</country></aff><aff xml:lang="ru" id="aff-2"><institution>РНЦХ им. Б.В. Петровского РАМН</institution><country>Russian Federation</country></aff><aff xml:lang="ru" id="aff-3"><institution>НИИЯФ им. Д.В. Скобельцына МГУ им. М.В. Ломоносова</institution><country>Russian Federation</country></aff><aff xml:lang="ru" id="aff-4"><institution>Государственная классическая академия им. Маймонида</institution><country>Russian Federation</country></aff><aff xml:lang="ru" id="aff-5"><institution>НПФ ООО «Гаммамед Софт»</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2013</year></pub-date><pub-date pub-type="epub"><day>05</day><month>10</month><year>2017</year></pub-date><volume>0</volume><issue>4</issue><fpage>16</fpage><lpage>25</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Крылов В.В., Природов А.В., Архипов И.В., Гаврилов А.В., Григорьева Е.В., Ганин Г.В., Ятченко А.М., 2017</copyright-statement><copyright-year>2017</copyright-year><copyright-holder xml:lang="ru">Крылов В.В., Природов А.В., Архипов И.В., Гаврилов А.В., Григорьева Е.В., Ганин Г.В., Ятченко А.М.</copyright-holder><copyright-holder xml:lang="en">Krylov V.V., Prirodov A.V., Arkhipov I.V., Gavrilov A.V., Grigorieva E.V., Ganin G.V., Iatchenko A.M.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.therjn.com/jour/article/view/55">https://www.therjn.com/jour/article/view/55</self-uri><abstract><p>Цель: изучить изменение потоков крови и основных параметров гемодинамики путем математического моделирования движения крови по артериям головного мозга и в интракраниальной аневризме при сохранении постоянного просвета сосуда и на фоне различных вариантов ангиоспазма. Материалы и методы: в работе использована методика компьютерного моделирования для определения изменений параметров гемодинамики аневризм, возникающих вследствие спазма приводящих артерий, на примере модели артериальной аневризмы, построенной с помощью компьютерного проектирования, а также на примерах 2 моделей аневризм базилярной и передней соединительной артерии, построенных на основе данных компьютерно-томографической ангиографии. В ходе исследования изучали влияние измененных скоростей и форм профилей потоков крови на напряжение пристеночного сдвига, особенно при изменениях потока, вызванных различными возможными вариантами спазма приводящих сосудов. Результаты: анализ гемодинамических характеристик моделей аневризм при разных видах спазма показал, что в случае сужения просвета приводящего сосуда скорость потока крови значительно увеличивается как в спазмированном участке, так и в самой аневризме, профиль потока существенно изменяется, особенно при наличии последовательных участков спазма приводящего сосуда либо в случае локализации аневризмы в месте соединения нескольких сосудов. В области места попадания ударной волны крови в аневризме возрастает напряжение пристеночного сдвига, что повышает риск повторного разрыва аневризмы. Заключение: математическое моделирование дает возможность количественно оценить, понять и визуально представить процессы, происходящие при прохождении крови по сосудам и в аневризме, а также изменения, возникающие на фоне ангиоспазма. Построение математических моделей изменений гемодинамики при ангиоспазме позволит понять и предвидеть характер осложнений, которые возможны в остром периоде кровоизлияния (например, повторный разрыв аневризмы), что имеет большое значение при определении хирургической тактики.</p></abstract><trans-abstract xml:lang="en"><p>Objective: to study the changes of blood streams and main hemodynamic parameters with the help of mathematical modeling of blood flow through cerebral arteries and in cerebral aneurysm when the vessel lumen is constant and in the case of various variants of angiospasm. Material and methods: the computer design method was used in our study to determine the changes of hemodynamic parameters in aneurysm, occurring because of angiospasm of afferent vessels by the example of the model of cerebral aneurysm created with the usage of computer design as well as by the example of 2 models of basilar aneurysm and anterior communicating aneurysm based on the data of computed tomography angiography. We examined the influence of changed blood flow velocity and shaped of blood flow profiles on to shear stress especially under conditions of blood flow changes because of various variants of afferent vessels angiospasm. Results: the analysis of hemodynamic characteristics of aneurysm models under condition of various variants of angiospasm revealed that the narrowing of the lumen of afferent vessel leads to significantly increase of the blood flow velocity both in the spastic area and in aneurysm itself, the profile of blood flow is significantly changed especially in the case of consequential spastic areas of afferent vessel or aneurysm localization at the junction of several vessels. The shear stress is increased at the area of shock blood wave hit in aneurysm that leads to increase the risk of repeated aneurysm rupture. Conclusion: the mathematical modeling allows assaying, understanding and visual presenting the processes occurring during blood flow through the vessels and in aneurysm as well as their changes because of angiospasm. The creating of mathematical models of hemodynamic changes under condition of angiospasm will allow understanding and predicting the character of complications which can be occur in acute period of hemorrhage (e.g. repeated rupture of aneurysm), that is of great importance for selection of surgical strategy.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>ангиоспазм</kwd><kwd>аневризма</kwd><kwd>математическое моделирование</kwd><kwd>церебральная гемодинамика</kwd><kwd>cerebral angiospasm</kwd><kwd>cerebral aneurysm</kwd><kwd>mathematical modeling</kwd><kwd>cerebral hemodynamics</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Гаврилов А.В., Архипов И.В., Куликов И.В., Парусников А.В., Ятченко А.М. 3D цифровой пациент. Математическое моделирование аневризм сосудов головного мозга.// Образовательный цикл “Сосудистая нейрохирургия”. 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