References

neurosurgery

Нейрохирургия

Russian journal of neurosurgery

1683-32952587-7569

Издательский дом "МедИНК"

neurosurgery-50

Research Article

ОБЗОРЫ ЛИТЕРАТУРЫ

LITERATURE REVIEW

Кортикальные дисплазии как эпилептогенные поражения

Cortical dysplasiae are as epileptogenic lesions

Степаненко

Алексей Юрьевич

Stepanenko

A. Yu.

a.stepanenko61@gmail.com

ГБОУЗ Городская клиническая больница № 12 Департамента Здравоохранения г. Москвы РФРоссияMoscow City Hospital No 12Russian Federation

2013

05102017

038591

2017

Степаненко А.Ю.

Stepanenko A.Y.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.therjn.com/jour/article/view/50

Кортикальные дисплазии представляют собой пороки развития коры, являющиеся частой причиной фармакорезистентной эпилепсии. Они часто выявляются в качестве патологического субстрата, лежащего в основе МР-негативной локализационно-обусловленной эпилепсии. Приведены основные данные о механизмах формирования дисплазий, различные классификации данных поражений и эпилептогенности различных типов дисплазий. Обсуждаются значение мультимодальной диагностики и инвазивных нейрофизиологических исследований в дооперационном обследовании больных, а также актуальные вопросы планирования хирургических вмешательств при различных вариантах эпилептогенных поражений, обусловленных кортикальными дисплазиями. Представлены различные методики резекционных и деафферентационных вмешательств. Рассматриваются вопросы выбора тактики хирургического лечения, являющиеся предметом дискуссий.

The cortical dysplasias are a kind of malformation due to abnormal cortical development which is a common cause of medically intractable epilepsy. Dysplasia is the frequent pathologic substrate of the MRI-negative localization-related epilepsy. In the review a specification on formation mechanisms of dysplasia, various classifications of the lesions and epileptogenicity of the different types of dysplasia are resulted. Value of multimodal diagnostics and invasive neurophysiological investigations in presurgical evaluation of the patients, and also actual questions of planning of surgical interventions at different variants of the epileptogenic caused by the cortical dysplasia are discussed. Various methods of the resective and deafferentation surgical procedures are presented. Questions of a choice of the surgical strategy, being a subject of discussions are considered.

кортикальная дисплазияэпилептогенные пораженияхирургическое лечение эпилепсииcortical dysplasiaepileptogenic lesionsepilepsy surgery

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The authors declare that there are no conflicts of interest present.