neurosurgeryНейрохирургияRussian journal of neurosurgery1683-32952587-7569Издательский дом "МедИНК"10.63769/1683-3295-2017-0-2-88-95neurosurgery-408Research ArticleОБЗОРЫ ЛИТЕРАТУРЫLITERATURE REVIEWПрименение регенеративных и остеоиндуктивных технологий в практической медицинеThe regenerative and osseoinductive technologies in applied medicineБулкинАнатолий АлексеевичBulkinA. A.anatolbulkin@gmail.comБоковАндрей ЕвгеньевичBokovA. E.andrei_bokov@mail.ruОлейникАлександр ЯковлевичOleinikA. Ya.aaleynik@yandex.ruМлявыхСергей ГеннадьевичMlyavykhS. G.spinedoc@bk.ruФГБУ Приволжский федеральный медицинский исследовательский центр Минздрава РоссииRussian Federation201724112017028895Copyright © Булкин А.А., Боков А.Е., Олейник А.Я., Млявых С.Г., 20172017Булкин А.А., Боков А.Е., Олейник А.Я., Млявых С.Г.Bulkin A.A., Bokov A.E., Oleinik A.Y., Mlyavykh S.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.therjn.com/jour/article/view/408

Проведен аналитический обзор литературы о современном состоянии вопроса применения клеточных технологий и тканевой инженерии при костной пластике и перспективам их использования при стабилизирующих вмешательствах на позвоночнике. Нами проанализировано 119 статей из базы данных PUBMED, Google Scholar в зарубежных рецензируемых периодических изданиях. Глубина поиска составила 27 лет (1989-2015 гг.). Обсуждены вопросы влияния факторов роста на костную регенерацию и формирование костного блока, оптимальные свойства костнозамещающего материала. Рассмотрено влияние стволовых клеток, медиаторов воспаления на процессы остеорепарации и остеоинтеграции.

The analysis of literature data concerning cell and tissue technologies in bone plastics and prospects of their usage in stabilizing interventions on vertebral column was conducted. Authors analyzed 119 articles from PUBMED and Google Scholar database in international peer-reviewed periodicals from 1989 to 2015. The growth factors enhancing bone regeneration and bone block formation, optimal properties of material for bone replacement as well as the influence of stem cells and inflammatory mediators for the processes of osteoreparation and osseointegration were discussed.

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The authors declare that there are no conflicts of interest present.