neurosurgeryНейрохирургияRussian journal of neurosurgery1683-32952587-7569Издательский дом "МедИНК"10.63769/1683-3295-2026-28-2-113-121neurosurgery-1852Research ArticleОБЗОР ЛИТЕРАТУРЫLITERATURE REVIEWМатериалы на основе шелка паутины для регенеративной медициныMaterials based on spider silk for regenerative medicinehttps://orcid.org/0000-0002-4317-8146ПятницкаяС. В.PiatnitskaiaS. V.

Светлана Викторовна Пятницкая 

450008 Уфа, ул. Ленина, 3 

Svetlana Viktorovna Piatnitskaia  

3 Lenina St., Ufa 450008 

pyatnickaya27@mail.ruhttps://orcid.org/0000-0002-0100-6100СафинШ. М.SafinSh. M.

450008 Уфа, ул. Ленина, 3 

3 Lenina St., Ufa 450008 

https://orcid.org/0009-0003-2986-5251ЗамановаР. А.ZamanovaR. A.

450008 Уфа, ул. Ленина, 3 

3 Lenina St., Ufa 450008 

https://orcid.org/0009-0006-3082-941XФайрушинаА. И.FairushinaA. I.

450008 Уфа, ул. Ленина, 3 

3 Lenina St., Ufa 450008 

https://orcid.org/0009-0002-9523-3837МахьяновД. З.MakhyanovD. Z.

450008 Уфа, ул. Ленина, 3 

3 Lenina St., Ufa 450008 

https://orcid.org/0009-0003-7003-4097АбдуллинаН. И.AbdullinaN. I.

450008 Уфа, ул. Ленина, 3 

3 Lenina St., Ufa 450008 

КирееваГ. Р.KireevaG. R.

450008 Уфа, ул. Ленина, 3 

3 Lenina St., Ufa 450008 

ФасхутдиновИ. Ф.FaskhutdinovI. F.

450008 Уфа, ул. Ленина, 3 

3 Lenina St., Ufa 450008 

https://orcid.org/0000-0003-4096-1087СмирновВ. А.SmirnovV. A.

129090 Москва, Большая Сухаревская пл., 3 

3 Bolshaya Sukharevskaya Ploshchad, Moscow 129090 

https://orcid.org/0000-0001-5256-0905КрыловВ. В.KrylovV. V.

129090 Москва, Большая Сухаревская пл., 3 

125367 Москва, Волоколамское шоссе, 80 

117513 Москва, ул. Островитянова, 1 

3 Bolshaya Sukharevskaya Ploshchad, Moscow 129090 

80 Volokolamskoye Shosse, Moscow 125367 

1 Ostrovityanova St., Moscow 117513 

https://orcid.org/0000-0003-2125-4897ПавловВ. Н.PavlovV. N.

450008 Уфа, ул. Ленина, 3 

3 Lenina St., Ufa 450008 

ФГБОУ ВО «Башкирский государственный медицинский университет» Минздрава РоссииРоссияBashkir State Medical University, Ministry of Health of RussiaRussian FederationГБУЗ г. Москвы «Научно-исследовательский институт скорой помощи им. Н.В. Склифосовского Департамента здравоохранения г. Москвы»РоссияSklifosovsky Research Institute for Emergency Medicine, Moscow Healthcare DepartmentRussian FederationГБУЗ г. Москвы «Научно-исследовательский институт скорой помощи им. Н.В. Склифосовского Департамента здравоохранения г. Москвы»; ФГБНУ «Российский центр неврологии и нейронаук»; ФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава РоссииРоссияSklifosovsky Research Institute for Emergency Medicine, Moscow Healthcare Department; Russian Center of Neurology and Neuroscience; N.I. Pirogov Russian National Research Medical University, Ministry of Health of RussiaRussian Federation202619062026282113121Copyright © Пятницкая С.В., Сафин Ш.М., Заманова Р.А., Файрушина А.И., Махьянов Д.З., Абдуллина Н.И., Киреева Г.Р., Фасхутдинов И.Ф., Смирнов В.А., Крылов В.В., Павлов В.Н., 20262026Пятницкая С.В., Сафин Ш.М., Заманова Р.А., Файрушина А.И., Махьянов Д.З., Абдуллина Н.И., Киреева Г.Р., Фасхутдинов И.Ф., Смирнов В.А., Крылов В.В., Павлов В.Н.Piatnitskaia S.V., Safin S.M., Zamanova R.A., Fairushina A.I., Makhyanov D.Z., Abdullina N.I., Kireeva G.R., Faskhutdinov I.F., Smirnov V.A., Krylov V.V., Pavlov V.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.therjn.com/jour/article/view/1852

Шелк паутины представляет собой необычайно прочный, гибкий, биосовместимый природный биоматериал, который становится привлекательным для проведения научных исследований с возможностью трансляции в клиническую практику. Самки пауковкругопрядов рода Nephila clavipes производят до 7 типов шелка, используя различные шелковые железы и прядильные органы, расположенные на заднем конце брюшка паука. Основными белками являются спидроины главной ампулы MaSp1 и MaSp2, которые могут быть использованы для создания рекомбинантной паутины в связи с ограничением сбора паутины в естественных условиях. В обзоре освещаются исследования, изучающие применение материалов на основе паучьего шелка в области тканевой инженерии in vitro. В частности, суммируются данные по применению двухмерных и трехмерных моделей и каркасов для тканевой инженерии с возможностью использования современных технологий, таких как биопечать. 

Spider silk is an unusually strong, flexible, biocompatible natural biomaterial that is becoming attractive for scientific research with the possibility of translation into clinical practice. Female orb-weaving spiders of the genus Nephila clavipes produce up to seven different types of silk, using various silk glands and spinning organs located at the posterior end of the spider’s abdomen. The main proteins are the main ampulla spidroins MaSp1 and MaSp2, which can be used to create recombinant spider silk due to the limitation of web collection in vivo. The review highlights studies dedicated to the use of spider silk-based materials in the field of tissue engineering in vitro. In particular, data on the use of two-dimensional and three-dimensional models and scaffolds for tissue engineering with the possibility of using modern technologies such as bioprinting are summarized. 

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The authors declare that there are no conflicts of interest present.