neurosurgeryНейрохирургияRussian journal of neurosurgery1683-32952587-7569Издательский дом "МедИНК"10.17650/1683-3295-2024-26-4-110-115neurosurgery-1617Research ArticleЛЕКЦИЯLECTUREРоль врожденного и приобретенного иммунитета в валлеровой дегенерации при размозжении периферических нервовThe role of innate and adaptive immunity in Wallerian degeneration in peripheral nerve crush injuryhttps://orcid.org/0000-0002-0927-4919BesinV.BesinV.

Valentinus Besin

Faculty of Medicine

Surabaya

Valentinus Besin

Faculty of Medicine

Surabaya

valentinusbesin@staff.ubaya.ac.idhttps://orcid.org/0000-0003-2038-6345NaesillaN.NaesillaN.

Naesilla Naesilla

Faculty of Medicine

Surabaya

Naesilla Naesilla

Faculty of Medicine

Surabaya

Universitity of SurabayaИндонезияUniversitity of SurabayaIndonesiaAirlangga UniversityИндонезияAirlangga UniversityIndonesia202426012025264110115Copyright © Besin V., Naesilla N., 20252025Besin V., Naesilla N.Besin V., Naesilla N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.therjn.com/jour/article/view/1617

   У некоторых пациентов развивается повреждение периферических нервов в результате травм, сопровождающихся сдавливанием тканей. Восстановление после травм периферических нервов часто бывает неудовлетворительным и требует месяцев или даже лет. Процесс восстановления связан как с врожденным иммунитетом, в частности шванновскими клетками, нейтрофилами и макрофагами, так и с приобретенным иммунитетом. Перед началом процесса регенерации два аспекта иммунной системы работают вместе, чтобы устранить миелин и разрушенные аксональные белки в ходе процесса валлеровой дегенерации.

   Some trauma patients develop peripheral nerve injury due to crush injuries resulting from severe trauma and blunt force. Recovery from peripheral nerve injuries is frequently inadequate and requires months or even years. This recovery process is associated with both the innate immune system, comprised of Schwann cells, neutrophils, and macrophages and the adaptive immune system. Prior to the regeneration process, the two immune systems work collaboratively to eliminate myelin and axon protein debris in Wallerian degeneration.

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The authors declare that there are no conflicts of interest present.