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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">neurosurgery</journal-id><journal-title-group><journal-title xml:lang="ru">Нейрохирургия</journal-title><trans-title-group xml:lang="en"><trans-title>Russian journal of neurosurgery</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1683-3295</issn><issn pub-type="epub">2587-7569</issn><publisher><publisher-name>Издательский дом "МедИНК"</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.17650/1683-3295-2024-26-3-13-22</article-id><article-id custom-type="elpub" pub-id-type="custom">neurosurgery-1567</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНАЯ РАБОТА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL REPORT</subject></subj-group></article-categories><title-group><article-title>Хирургическое лечение эпилепсии в Пермском крае</article-title><trans-title-group xml:lang="en"><trans-title>Surgical treatment of epilepsy in the Perm region</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5222-0628</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Штадлер</surname><given-names>Д. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Shtadler</surname><given-names>D. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>614107 Пермь, ул. Ким, 2</p></bio><bio xml:lang="en"><p>2 Kim St., Perm 614107</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7584-3083</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Штадлер</surname><given-names>В. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Shtadler</surname><given-names>V. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Владислав Дмитриевич Штадлер</p><p>614107 Пермь, ул. Ким, 2;</p><p>117997 Москва, ул. Островитянова, 1</p></bio><bio xml:lang="en"><p>Vladislav Dmitrievich Shtadler</p><p>2 Kim St., Perm 614107;</p><p>1 Ostrovityanova St., Moscow 117997</p></bio><email xlink:type="simple">vladislav.shtadler@gmail.com</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7341-797X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Староверов</surname><given-names>М. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Staroverov</surname><given-names>M. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>614107 Пермь, ул. Ким, 2;</p><p>117513 Москва, ул. Островитянова, 1, стр. 10</p></bio><bio xml:lang="en"><p>2 Kim St., Perm 614107;</p><p>Bld. 10, 1 Ostrovityanova St., Moscow 117513</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1744-492X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Фукалов</surname><given-names>Г. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Fukalov</surname><given-names>G. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>614000 Пермь, ул. Петропавловская, 26</p></bio><bio xml:lang="en"><p>26 Petropavlovskaya St., Perm 614000</p></bio><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0000-244X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хиревич</surname><given-names>Д. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Khirevich</surname><given-names>D. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>614107 Пермь, ул. Ким, 2</p></bio><bio xml:lang="en"><p>2 Kim St., Perm 614107</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1475-858X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Балакина</surname><given-names>Е. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Balakina</surname><given-names>E. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>614107 Пермь, ул. Ким, 2</p></bio><bio xml:lang="en"><p>2 Kim St., Perm 614107</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6911-0975</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Трифонов</surname><given-names>И. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Trifonov</surname><given-names>I. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>127006 Москва, ул. Долгоруковская, 4</p></bio><bio xml:lang="en"><p>4 Dolgorukovskaya St., Moscow 127006</p></bio><xref ref-type="aff" rid="aff-5"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5256-0905</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Крылов</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Krylov</surname><given-names>V. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>117997 Москва, ул. Островитянова, 1;</p><p>117513 Москва, ул. Островитянова, 1, стр. 10;</p><p>129090 Москва, Большая Сухаревская пл., 3</p></bio><bio xml:lang="en"><p>1 Ostrovityanova St., Moscow 117997;</p><p>Bld. 10, 1 Ostrovityanova St., Moscow 117513;</p><p>3 Bolshaya Sukharevskaya Sq., Moscow 129090</p></bio><xref ref-type="aff" rid="aff-6"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ГАУЗ Пермского края «Городская клиническая больница № 4»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Perm Region City Clinical Hospital No. 4</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ГАУЗ Пермского края «Городская клиническая больница № 4»;&#13;
ФГАОУ ВО «Российский научно-исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Perm Region City Clinical Hospital No. 4;&#13;
N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ГАУЗ Пермского края «Городская клиническая больница № 4»;&#13;
ФГБУ «Федеральный центр мозга и нейротехнологий» Федерального медико-биологического агентства</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Perm Region City Clinical Hospital No. 4;&#13;
Federal Center for Brain and Neurotechnologies, Federal Medical and Biological Agency of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>ФГБОУ ВО «Пермский государственный медицинский университет им. академика Е.А. Вагнера» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>E.A. Vagner Perm State Medical University, Ministry of Health of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-5"><aff xml:lang="ru"><institution>ФГБОУ ВО «Российский университет медицины» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Russian University of Medicine, Ministry of Health of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-6"><aff xml:lang="ru"><institution>ФГАОУ ВО «Российский научно-исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России;&#13;
ФГБУ «Федеральный центр мозга и нейротехнологий» Федерального медико-биологического агентства;&#13;
ГБУЗ г. Москвы «Научно-исследовательский институт скорой помощи им. Н.В. Склифосовского Департамента здравоохранения г. Москвы»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia;&#13;
Federal Center for Brain and Neurotechnologies, Federal Medical and Biological Agency of Russia;&#13;
N.V. Sklifosovsky Research Institute for Emergency Medicine, Moscow Healthcare Department</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>05</day><month>09</month><year>2024</year></pub-date><volume>26</volume><issue>3</issue><fpage>13</fpage><lpage>22</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Штадлер Д.И., Штадлер В.Д., Староверов М.С., Фукалов Г.А., Хиревич Д.Д., Балакина Е.М., Трифонов И.С., Крылов В.В., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Штадлер Д.И., Штадлер В.Д., Староверов М.С., Фукалов Г.А., Хиревич Д.Д., Балакина Е.М., Трифонов И.С., Крылов В.В.</copyright-holder><copyright-holder xml:lang="en">Shtadler D.I., Shtadler V.D., Staroverov M.S., Fukalov G.A., Khirevich D.D., Balakina E.M., Trifonov I.S., Krylov V.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.therjn.com/jour/article/view/1567">https://www.therjn.com/jour/article/view/1567</self-uri><abstract><p>В Пермском крае хирургическое лечение пациентов с фармакорезистентными формами эпилепсии началось с 2020 г. в рамках пилотного проекта «Организация системы хирургической помощи пациентам с фармакорезистентными формами эпилепсии в Российской Федерации». В статье представлена текущая практика за период 2020–2022 гг., которая включает алгоритм отбора на хирургическое лечение, виды вмешательств, полученные осложнения на различных этапах диагностики и в раннем послеоперационном периоде, а также ближайшие исходы. Предложен проект организации противоэпилептической службы в Пермском крае.</p></abstract><trans-abstract xml:lang="en"><p>Surgical treatment of epilepsy in Perm Region started in 2020 as a part of project “Organization of a system of surgical care for patients with Drug-Resistant Epilepsy in the Russian Federation”. This article presents the current practice for the period 2020–2022, which includes the selection algorithm for the surgical procedure, surgical methods, early and long-term complications ofsurgical treatment and diagnostics, and early outcomes. We suggest the project of the against epilepsy in Perm Region.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>фармакорезистентная эпилепсия</kwd><kwd>пороки развития головного мозга</kwd><kwd>последствия черепно-мозговой травмы</kwd><kwd>хирургическое лечение</kwd></kwd-group><kwd-group xml:lang="en"><kwd>drug-resistant epilepsy</kwd><kwd>brain malformations</kwd><kwd>sequelae of traumatic brain injury</kwd><kwd>surgical treatment</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">GBD 2016 Epilepsy Collaborators. Global, regional, and national burden of epilepsy, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol 2019;18(4):357–75. DOI: 10.1016/S1474-4422(18)30454-X</mixed-citation><mixed-citation xml:lang="en">GBD 2016 Epilepsy Collaborators. Global, regional, and national burden of epilepsy, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol 2019;18(4):357–75. DOI: 10.1016/S1474-4422(18)30454-X</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Гехт А.Б. Эпидемиология и фармакоэкономические аспекты эпилепсии. Журнал неврологии и психиатрии им. C.С. Корсакова 2005;105(8):63–5.</mixed-citation><mixed-citation xml:lang="en">Gekht A.B. Epidemiology and economic aspects of epilepsy. Zhurnal Nevrologii i psikhiatrii im. S.S. Korsakova = Korsakov’s Journal of Neurology and Psychiatry 2005;105(8):63–5. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Sultana B., Panzini M.-A., Carpentier A.V. et al. Incidence andprevalence of drug-resistant epilepsy: a systematic review and meta-analysis. Neurology 2021;96(17):805–17. DOI: 10.1212/WNL.0000000000011839</mixed-citation><mixed-citation xml:lang="en">Sultana B., Panzini M.-A., Carpentier A.V. et al. Incidence andprevalence of drug-resistant epilepsy: a systematic review and meta-analysis. Neurology 2021;96(17):805–17. DOI: 10.1212/WNL.0000000000011839</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Maguire M.J., Jackson C.F., Marson A.G., Nevitt S.J. Treatments for the prevention of Sudden Unexpected Death in Epilepsy (SUDEP). Cochrane Database Syst Rev 2020;2020(4):CD011792. DOI: 10.1002/14651858.cd011792.pub3</mixed-citation><mixed-citation xml:lang="en">Maguire M.J., Jackson C.F., Marson A.G., Nevitt S.J. Treatments for the prevention of Sudden Unexpected Death in Epilepsy (SUDEP). Cochrane Database Syst Rev 2020;2020(4):CD011792. DOI: 10.1002/14651858.cd011792.pub3</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Белоусова Е.Д., Школьникова М.А. Внезапная смерть и генетические эпилептические энцефалопатии: роль нейрокардиальных генов. Эпилепсия и пароксизмальные состояния 2018;10(3):63–70. DOI: 10.17749/2077-8333.2018.10.3.063-070</mixed-citation><mixed-citation xml:lang="en">Belousova E.D., Shkolnikova M.A. Sudden unexpected death in genetic epileptic encephalopathies: a role of neurocardiac genes. Epilepsiya i paroksizmalnye sostoyaniya = Epilepsy and Paroxysmal Conditions 2018;10(3):63–70. (In Russ.). DOI: 10.17749/2077-8333.2018.10.3.063-070</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Крылов В.В., Гусев Е.И., Гехт А.Б. и др. История развития хирургического лечения эпилепсии в Российской Федерации. Журнал неврологии и психиатрии им. C.С. Корсакова 2016;116(9–2):6–12. DOI: 10.17116/jnevro2016116926-12</mixed-citation><mixed-citation xml:lang="en">Krylov V.V., Gusev E.I., Gekht A.B. et al. The history of surgical treatment of epilepsy in the Russian Federation. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova = Korsakov’s Journal of Neurology and Psychiatry 2016;116(9–2):6–12. (In Russ.). DOI: 10.17116/jnevro2016116926-12</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Крылов В.В., Гехт А.Б., Трифонов И.С. и др. Ранние и отдаленные результаты хирургического лечения фармакорезистентных форм эпилепсии. Российский неврологический журнал 2022;27(1):52–61. DOI: 10.30629/2658-7947-2022-27-1-52-61</mixed-citation><mixed-citation xml:lang="en">Krylov V.V., Gekht A.B., Trifonov I.S. et al. Early and long-term outcomes of surgical treatment of patients with drug-resistant epilepsy. Rossiyskiy nevrologicheskiy zhurnal = Russian Neurological Journal 2022;27(1):52–61. (In Russ.). DOI: 10.30629/2658-7947-2022-27-1-52-61</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Lamberink H.J., Otte W.M., Blumcke I. et al. Seizure outcome and use of antiepileptic drugs after epilepsy surgery according to histopathological diagnosis: a retrospective multicentre cohort study. Lancet Neurol 2020;19(9):748–57. DOI: 10.1016/S1474-4422(20)30220-9</mixed-citation><mixed-citation xml:lang="en">Lamberink H.J., Otte W.M., Blumcke I. et al. Seizure outcome and use of antiepileptic drugs after epilepsy surgery according to histopathological diagnosis: a retrospective multicentre cohort study. Lancet Neurol 2020;19(9):748–57. DOI: 10.1016/S1474-4422(20)30220-9</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
