neurosurgeryНейрохирургияRussian journal of neurosurgery1683-32952587-7569Издательский дом "МедИНК"10.17650/1683-3295-2024-26-2-82-90neurosurgery-1533Research ArticleЛЕКЦИЯLECTUREМожет ли полное иссечение травмированного участка спинного мозга приводить к положительным результатам?Can a complete excision of the injured site of the spinal cord lead to positive results?https://orcid.org/0000-0002-9413-3167Лебенштейн-ГумовскиМ. В.Lebenstein-GumovskiM. V.

Михаил Владимирович Лебенштейн‑Гумовски 

129090 Москва, Большая Сухаревская пл., 3

Mikhail V. Lebenstein‑Gumovski 

3 Bolshaya Sukharevskaya Sq., Moscow 129090

Dr.lebenstein.g@gmail.comhttps://orcid.org/0000-0003-3515-8329ГриньА. А.GrinA. A.

129090 Москва, Большая Сухаревская пл., 3,

117997 Москва, ул. Островитянова, 1

3 Bolshaya Sukharevskaya Sq., Moscow 129090,

1 Ostrovitianov St., Moscow 11799

ГБУЗ «Научно-исследовательский институт скорой помощи им. Н.В. Склифосовского Департамента здравоохранения города Москвы»РоссияN.V. Sklifosovsky Research Institute for Emergency Medicine, Moscow Healthcare DepartmentRussian FederationГБУЗ «Научно-исследовательский институт скорой помощи им. Н.В. Склифосовского Департамента здравоохранения города Москвы»; ФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава РоссииРоссияN.V. Sklifosovsky Research Institute for Emergency Medicine, Moscow Healthcare Department; N.I. Pirogov Russian National Research Medical University, Ministry of Health of RussiaRussian Federation2024070620242628290Copyright © Лебенштейн-Гумовски М.В., Гринь А.А., 20242024Лебенштейн-Гумовски М.В., Гринь А.А.Lebenstein-Gumovski M.V., Grin A.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.therjn.com/jour/article/view/1533

До настоящего времени не разработаны успешные способы восстановления поврежденного спинного мозга и его функций при тяжелой спинномозговой травме, такой как ушиб спинного мозга, его разрыв или пересечение. Во многом это связано с отсутствием методик лечения, направленных на цепь патогенетических процессов, происходящих в нервной ткани после травмы. Тема восстановления функций спинного мозга зачастую считается нежелательной для обсуждения и находится под влиянием клинических стереотипов. В статье предлагается рассмотреть метод лечения спинномозговой травмы, основанный на современных данных о патофизиологических процессах в месте повреждения и за его пределами. Использование новых данных и достижений экспериментальной науки о тяжелой травме спинного мозга может явиться серьезным шагом к разработке новых методик лечения этой патологии.

Until now, there are no successful ways to restore the damaged spinal cord and its functions in severe spinal cord injury such as spinal cord contusion, rupture or intersection. This is largely due to the lack of treatment methods aimed at the chain of pathogenetic processes occurring in the nervous tissue after injury. The topic of restoration of spinal cord functions is taboo, often undesirable for discussion, and is influenced by clinical stereotypes. The article proposes to consider the method of treatment of spinal cord injury, using modern data, taking into account emerging pathophysiological processes at the site of injury and beyond. The use of new data and achievements of experimental science on severe spinal cord injury can be a serious step towards the development of new methods for the treatment of this pathology.

спинальная травматравма спинного мозгаваллеровское перерождениедегенерацияглиальный рубецполиэтиленгликольхитозанклеточные матрицыстволовые клеткикордэктомиякорпорэктомиякорпородезспондилодезэксайтотоксичностьаксональный ростspinal injuryspinal cord injuryWallerian degenerationdegenerationglial scarpolyethylene glycolchitosancell matricesstem cellscordectomycorporectomycorporodesisspinal fusionexcitotoxicityaxonal growthReferencesIllis L.S. Central nervous system regeneration does not occur. Spinal Cord 2012;50(4):259–63. DOI: 10.1038/sc.2011.132Illis L.S. Central nervous system regeneration does not occur. Spinal Cord 2012;50(4):259–63. DOI: 10.1038/sc.2011.132Stewart F.T., Harte R.H. A case of severed spinal cord in which myelorrhaphy was followed by partial return of function. Philadelphia Med J 1902;9:1016–20.Stewart F.T., Harte R.H. A case of severed spinal cord in which myelorrhaphy was followed by partial return of function. Philadelphia Med J 1902;9:1016–20.Freeman L.W. Editors Proceedings, X Congreso Latinoamericano de Neurochirurgia. Brazil: Editorial Don Bosco, 1963. Pp. 135–44.Freeman L.W. Editors Proceedings, X Congreso Latinoamericano de Neurochirurgia. Brazil: Editorial Don Bosco, 1963. Pp. 135–44.Freeman L.W. Return of spinal cord function in mammals after transecting lesions. Ann NY Acad Med Sci 1954;58(5):564–9. DOI: 10.1111/j.1749-6632.1954.tb54093.xFreeman L.W. Return of spinal cord function in mammals after transecting lesions. Ann NY Acad Med Sci 1954;58(5):564–9. DOI: 10.1111/j.1749-6632.1954.tb54093.xFreeman L.W. Experimental observations upon axonal regeneration in the transected spinal cord of mammals. Clin Neurosurg 1962;8:294–319. DOI: 10.1093/neurosurgery/8.cn_suppl_1.294Freeman L.W. Experimental observations upon axonal regeneration in the transected spinal cord of mammals. Clin Neurosurg 1962;8:294–319. DOI: 10.1093/neurosurgery/8.cn_suppl_1.294Карагяур М.Н., Макаревич П.И., Шевченко Е.К. и др. Современные подходы к регенерации периферических нервов после травмы: перспективы генной и клеточной терапии. Гены и клетки 2017;12(1):6–14. DOI: 10.23868/gc120633Karagyaur M.N., Makarevich P.I., Shevchenko E.K. et al. Modern approaches to peripheral nerve regeneration after injury: the prospects of gene and cell therapy. Geny i kletki = Genes & Cells 2017;12(1):6–14. (In Russ.). DOI: 10.23868/gc120633Александров Ю.И., Анохин К.В., Безденежных Б.Н. и др. Нейрон. Обработка сигналов. Пластичность. Моделирование: фундаментальное руководство. Тюмень: Изд-во Тюменского гос. ун-та, 2008. 548 c.Aleksandrov Yu.I., Anokhin K.V., Bezdenezhnykh B.N. et al. Neuron. Signal processing. Plastic. Modeling: A Fundamental Guide. Tyumen: Izd-vo Tumenskogo gos. un-ta, 2008. 548 p. (In Russ.).Rowland J.W., Hawryluk G.W., Kwon B., Fehlings M.G. Current status of acute spinal cord injury pathophysiology and emerging therapies: promise on the horizon. Neurosurg Focus 2008;25(5):E2. DOI: 10.3171/FOC.2008.25.11.E2Rowland J.W., Hawryluk G.W., Kwon B., Fehlings M.G. Current status of acute spinal cord injury pathophysiology and emerging therapies: promise on the horizon. Neurosurg Focus 2008;25(5):E2. DOI: 10.3171/FOC.2008.25.11.E2Chen Y., Tang Y., Vogel L.C., Devivo M.J. Causes of spinal cord injury. Top Spinal Cord Inj Rehabil 2013;19(1):1–8. DOI: 10.1310/sci1901-1Chen Y., Tang Y., Vogel L.C., Devivo M.J. Causes of spinal cord injury. Top Spinal Cord Inj Rehabil 2013;19(1):1–8. DOI: 10.1310/sci1901-1Park D.H., Lee J.H., Borlongan C.V. et al. Transplantation of umbilical cord blood stem cells for treating spinal cord injury. Stem Cell Rev Rep 2011;7(1):181–94. DOI: 10.1007/s12015-010-9163-0Park D.H., Lee J.H., Borlongan C.V. et al. Transplantation of umbilical cord blood stem cells for treating spinal cord injury. Stem Cell Rev Rep 2011;7(1):181–94. DOI: 10.1007/s12015-010-9163-0Silva N.A., Sousa N., Reis R.L., Salgado A.J. From basics to clinical: a comprehensive review on spinal cord injury. Prog Neurobiol 2014;114:25–57. DOI: 10.1016/j.pneurobio.2013.11.002Silva N.A., Sousa N., Reis R.L., Salgado A.J. From basics to clinical: a comprehensive review on spinal cord injury. Prog Neurobiol 2014;114:25–57. DOI: 10.1016/j.pneurobio.2013.11.002Смирнов В.А., Гринь А.А., Крылов В.В. Регенеративные методы лечения травмы спинного мозга. Обзор литературы. Часть 1. Нейрохирургия 2019;21(2):66–75. DOI: 10.17650/1683-3295-2019-21-2-66-75Smirnov V.A., Grin A.A., Krylov V.V. Regenerative methods of treatment of spinal cord injury. Literature review. Part 1. Neirokhirurgiya = Russian Journal of Neurosurgery 2019;21(2):66– 75. (In Russ.). DOI: 10.17650/1683-3295-2019-21-2-66-75Hechler D., Nitsch R., Hendrix S. Green-fluorescent-proteinexpressing mice as models for the study of axonal growth and regeneration in vitro. Brain Res Rev 2006;52(1):160–9. DOI: 10.1016/j.brainresrev.2006.01.005Hechler D., Nitsch R., Hendrix S. Green-fluorescent-proteinexpressing mice as models for the study of axonal growth and regeneration in vitro. Brain Res Rev 2006;52(1):160–9. DOI: 10.1016/j.brainresrev.2006.01.005Önger M.E., Delibaş B., Türkmen A.P. et al. The role of growth factors in nerve regeneration. Drug Discov Ther 2017;10(6): 285–91. DOI: 10.5582/ddt.2016.01058Önger M.E., Delibaş B., Türkmen A.P. et al. The role of growth factors in nerve regeneration. Drug Discov Ther 2017;10(6): 285–91. DOI: 10.5582/ddt.2016.01058Thomson C.E., Hunter A.M., Griffiths I.R. et al. Murine spinal cord explants: a model for evaluating axonal growth and myelination in vitro. J Neurosci Res 2006;84(8):1703–15. DOI: 10.1002/jnr.21084Thomson C.E., Hunter A.M., Griffiths I.R. et al. Murine spinal cord explants: a model for evaluating axonal growth and myelination in vitro. J Neurosci Res 2006;84(8):1703–15. DOI: 10.1002/jnr.21084Auerbach A.D., Liu Q., Ghosh R. et al. Prenatal identification of potential donors for umbilical cord blood transplantation for Fanconi anemia. Transfusion 1990;30(8):682–7. DOI: 10.1046/j.1537-2995.1990.30891020324.xAuerbach A.D., Liu Q., Ghosh R. et al. Prenatal identification of potential donors for umbilical cord blood transplantation for Fanconi anemia. Transfusion 1990;30(8):682–7. DOI: 10.1046/j.1537-2995.1990.30891020324.xBeattie M.S., Hermann G.E., Rogers R.C., Bresnahan J.C. Cell death in models of spinal cord injury. Prog Brain Res 2002;137: 37–47. DOI: 10.1016/s0079-6123(02)37006-7Beattie M.S., Hermann G.E., Rogers R.C., Bresnahan J.C. Cell death in models of spinal cord injury. Prog Brain Res 2002;137: 37–47. DOI: 10.1016/s0079-6123(02)37006-7Hall E.D., Springer J.E. Neuroprotection and acute spinal cord injury: a reappraisal. NeuroRx 2004;1(1):80–100. DOI: 10.1602/neurorx.1.1.80Hall E.D., Springer J.E. Neuroprotection and acute spinal cord injury: a reappraisal. NeuroRx 2004;1(1):80–100. DOI: 10.1602/neurorx.1.1.80Gris P., Tighe A., Levin D. et al. Transcriptional regulation of scar gene expression in primary astrocytes. Glia 2007;55(11):1145–55. DOI: 10.1002/glia.20537Gris P., Tighe A., Levin D. et al. Transcriptional regulation of scar gene expression in primary astrocytes. Glia 2007;55(11):1145–55. DOI: 10.1002/glia.20537Dougherty K.J., Hochman S. Spinal cord injury causes plasticity in a subpopulation of lamina I GABAergic interneurons. J Neurophysiol 2008;100(1):212–23. DOI: 10.1152/jn.01104.2007Dougherty K.J., Hochman S. Spinal cord injury causes plasticity in a subpopulation of lamina I GABAergic interneurons. J Neurophysiol 2008;100(1):212–23. DOI: 10.1152/jn.01104.2007Stab wounds of the spinal cord. Br Med J 1978;1(6120):1093–4.Stab wounds of the spinal cord. Br Med J 1978;1(6120):1093–4.Manzone P., Domenech V., Forlino D. Stab injury of the spinal cord surgically treated. J Spinal Disord 2001;14(3):264–7. DOI: 10.1097/00002517-200106000-00014Manzone P., Domenech V., Forlino D. Stab injury of the spinal cord surgically treated. J Spinal Disord 2001;14(3):264–7. DOI: 10.1097/00002517-200106000-00014Dlouhy B.J., Dahdaleh N.S., Howard M.A. 3rd. Radiographic and intraoperative imaging of a hemisection of the spinal cord resulting in a pure brown-séquard syndrome: сase report and review of the literature. J Neurosurg Sci 2013;57(1):81–6.Dlouhy B.J., Dahdaleh N.S., Howard M.A. 3rd. Radiographic and intraoperative imaging of a hemisection of the spinal cord resulting in a pure brown-séquard syndrome: сase report and review of the literature. J Neurosurg Sci 2013;57(1):81–6.Canavero S. The “Gemini” spinal cord fusion protocol: reloaded. Surg Neurol Int 2015;6:18. DOI: 10.4103/2152-7806.150674Canavero S. The “Gemini” spinal cord fusion protocol: reloaded. Surg Neurol Int 2015;6:18. DOI: 10.4103/2152-7806.150674Акшулаков С.К., Керимбаев Т.Т., Алейников В.Г. Обзор методов восстановления проводимости травмированного участка спинного мозга сочетанием комбинированных путей восстановления поврежденного участка и стимуляции регенерации аксонов. Нейрохирургия и неврология Казахстана 2015;3(40):40–4.Akshulakov S.K., Kerimbaev T.T., Aleinikov V.G. A review of methods for restoring the conduction of an injured area of the spinal cord by a combination of combined ways of restoring the damaged area and stimulating axon regeneration. Neirokhirurgiya i nevrologiya Kazakhstana = Neurosurgery and Neurology of Kazakhstan 2015;3(40):40–4. (In Russ.).Аганесов А.Г. Хирургическое лечение осложненной травмы позвоночника – прошлое и настоящее. Хирургия. Журнал им. Н.И. Пирогова 2013;1:5–12.Aganesov A.G. The future and the past of surgery for the complicated spine trauma. Hirurgiya. Zhurnal im. N.I. Pirogova = Pirogov Russian Journal of Surgery 2013;1:5–12. (In Russ.).Sledge J., Graham W.A., Westmoreland S. et al. Spinal cord injury models in non human primates: are lesions created by sharp instruments relevant to human injuries? Med Hypotheses 2013;81(4):747–8. DOI: 10.1016/j.mehy.2013.07.040Sledge J., Graham W.A., Westmoreland S. et al. Spinal cord injury models in non human primates: are lesions created by sharp instruments relevant to human injuries? Med Hypotheses 2013;81(4):747–8. DOI: 10.1016/j.mehy.2013.07.040Гринь А.А., Кордонский А.Ю., Львов И.С. и др. Фактор времени в хирургии позвоночно-спинальной травмы (обзор литературы). Нейрохирургия 2018;20(3):81–90. DOI: 10.17650/1683-3295-2018-20-3-81-90Grin A.A., Kordonskiy A.Yu., Lʼvov I.S. et al. The timing in surgery of spinal trauma (a review). Neirokhirurgiya = Russian Journal of Neurosurgery 2018;20(3):81–90. (In Russ.). DOI: 10.17650/1683-3295-2018-20-3-81-90Yoshida Y., Kataoka H., Kanchiku T. et al. Transection method for shortening the rat spine and spinal cord. Exp Ther Med 2013;5(2):384–8. DOI: 10.3892/etm.2012.841Yoshida Y., Kataoka H., Kanchiku T. et al. Transection method for shortening the rat spine and spinal cord. Exp Ther Med 2013;5(2):384–8. DOI: 10.3892/etm.2012.841Assinck P., Duncan G.J., Hilton B.J. et al. Cell transplantation therapy for spinal cord injury. Nat Neurosci 2017;20(5):637–47. DOI: 10.1038/nn.4541Assinck P., Duncan G.J., Hilton B.J. et al. Cell transplantation therapy for spinal cord injury. Nat Neurosci 2017;20(5):637–47. DOI: 10.1038/nn.4541Dalamagkas K., Tsintou M., Seifalian A., Seifalian A.M. Translational regenerative therapies for chronic spinal cord injury. Int J Mol Sci 2018;19(6):1776. DOI: 10.3390/ijms19061776Dalamagkas K., Tsintou M., Seifalian A., Seifalian A.M. Translational regenerative therapies for chronic spinal cord injury. Int J Mol Sci 2018;19(6):1776. DOI: 10.3390/ijms19061776Donovan J., Kirshblum S. Clinical trials in traumatic spinal cord injury. Neurotherapeutics 2018;15(3):654–68. DOI: 10.1007/s13311-018-0632-5Donovan J., Kirshblum S. Clinical trials in traumatic spinal cord injury. Neurotherapeutics 2018;15(3):654–68. DOI: 10.1007/s13311-018-0632-5David S., Aguayo A.J. Axonal elongation into peripheral nervous system “bridges” after central nervous system injury in adult rats. Science 1981;214(4523):931–3. DOI: 10.1126/science.6171034David S., Aguayo A.J. Axonal elongation into peripheral nervous system “bridges” after central nervous system injury in adult rats. Science 1981;214(4523):931–3. DOI: 10.1126/science.6171034Tabakow P., Raisman G., Fortuna W. et al. Functional regeneration of supraspinal connections in a patient with transected spinal cord following transplantation of bulbar olfactory ensheathing cells with peripheral nerve bridging. Cell Transplant 2014;23(12):1631–55. DOI: 10.3727/096368914X685131Tabakow P., Raisman G., Fortuna W. et al. Functional regeneration of supraspinal connections in a patient with transected spinal cord following transplantation of bulbar olfactory ensheathing cells with peripheral nerve bridging. Cell Transplant 2014;23(12):1631–55. DOI: 10.3727/096368914X685131Fitch M.T., Silver J. CNS injury, glial scars, and inflammation: inhibitory extracellular matrices and regeneration failure. Exp Neurol 2008;209(2):294–301. DOI: 10.1016/j.expneurol.2007.05.014Fitch M.T., Silver J. CNS injury, glial scars, and inflammation: inhibitory extracellular matrices and regeneration failure. Exp Neurol 2008;209(2):294–301. DOI: 10.1016/j.expneurol.2007.05.014Moore D.L., Blackmore M.G., Hu Y. et al. KLF family members regulate intrinsic axon regeneration ability. Science 2009;326(5950):298–301. DOI: 10.1126/science.1175737Moore D.L., Blackmore M.G., Hu Y. et al. KLF family members regulate intrinsic axon regeneration ability. Science 2009;326(5950):298–301. DOI: 10.1126/science.1175737Ankeny D.P., McTigue D.M., Jakeman L.B. Bone marrow transplants provide tissue protection and directional guidance for axons after contusive spinal cord injury in rats. Exp Neurol 2004;190(1):17–31. DOI: 10.1016/j.expneurol.2004.05.045Ankeny D.P., McTigue D.M., Jakeman L.B. Bone marrow transplants provide tissue protection and directional guidance for axons after contusive spinal cord injury in rats. Exp Neurol 2004;190(1):17–31. DOI: 10.1016/j.expneurol.2004.05.045Большаков И.Н., Кривопалов В.А., Каптюк Г.И. и др. Трансплантация клеточной полисахаридной подложки при частичном спинальном разрыве у крыс. Фундаментальные исследования 2012;2:31–4.Bolshakov I.N., Krivopalov V.A., Kaptyuk G.I. et al. Transplantation of a cellular polysaccharide scaffold for partial spinal rupture in rats. Fundamentalnye issledovaniya = Fundamental Research 2012;2:31–4. (In Russ.).Смирнов В.А., Гринь А.А. Регенеративные методы лечения травмы спинного мозга. Обзор литературы. Часть 4. Нейрохирургия 2020;22(1):83–92. DOI: 10.17650/1683-3295-2020-22-1-83-92Smirnov V. A., Grin A.A. Regenerative treatment of spinal cord injury. Literature review. Part 4. Neirokhirurgiya = Russian Journal of Neurosurgery 2020;22(1):83–92. (In Russ.). DOI: 10.17650/1683-3295-2020-22-1-83-92Gage F.H., Temple S. Neural stem cells: generating and regenerating the brain. Neuron 2013;80(3):588–601. DOI: 10.1016/j.neuron.2013.10.037Gage F.H., Temple S. Neural stem cells: generating and regenerating the brain. Neuron 2013;80(3):588–601. DOI: 10.1016/j.neuron.2013.10.037Kouhzaei S., Rad I., Mousavidoust S., Mobasheri H. Protective effect of low molecular weight polyethylene glycol on the repair of experimentally damaged neural membranes in ratʼs spinal cord. Neurol Res 2013;35(4):415–23. DOI: 10.1179/1743132812Y.0000000133Kouhzaei S., Rad I., Mousavidoust S., Mobasheri H. Protective effect of low molecular weight polyethylene glycol on the repair of experimentally damaged neural membranes in ratʼs spinal cord. Neurol Res 2013;35(4):415–23. DOI: 10.1179/1743132812Y.0000000133Lu X., Perera T.H., Aria A.B., Callahan L.A.S. Polyethylene glycol in spinal cord injury repair: a critical review. J Exp Pharmacol 2018;10:37–49. DOI: 10.2147/JEP.S148944Lu X., Perera T.H., Aria A.B., Callahan L.A.S. Polyethylene glycol in spinal cord injury repair: a critical review. J Exp Pharmacol 2018;10:37–49. DOI: 10.2147/JEP.S148944Kim C.Y., Sikkema W.K.A., Kim J. et al. Effect of Graphene Nanoribbons (TexasPEG) on locomotor function recovery in a rat model of lumbar spinal cord transection. Neural Regen Res 2018;13(8):1440–6. DOI: 10.4103/1673-5374.235301Kim C.Y., Sikkema W.K.A., Kim J. et al. Effect of Graphene Nanoribbons (TexasPEG) on locomotor function recovery in a rat model of lumbar spinal cord transection. Neural Regen Res 2018;13(8):1440–6. DOI: 10.4103/1673-5374.235301Ren S., Liu Z.H., Wu Q. et al. Polyethylene glycol-induced motor recovery after total spinal transection in rats. CNS Neurosci Ther 2017;23(8):680–5. DOI: 10.1111/cns.12713Ren S., Liu Z.H., Wu Q. et al. Polyethylene glycol-induced motor recovery after total spinal transection in rats. CNS Neurosci Ther 2017;23(8):680–5. DOI: 10.1111/cns.12713Sretavan D.W., Chang W., Hawkes E. et al. Microscale surgery on single axons. Neurosurgery 2005;57(4):635–46; discussion 635–46.Sretavan D.W., Chang W., Hawkes E. et al. Microscale surgery on single axons. Neurosurgery 2005;57(4):635–46; discussion 635–46.Canavero S., Ren X., Kim C.Y. Reconstructing the severed spinal cord. Surg Neurol Int 2017;8:285. DOI: 10.4103/sni.sni_406_17Canavero S., Ren X., Kim C.Y. Reconstructing the severed spinal cord. Surg Neurol Int 2017;8:285. DOI: 10.4103/sni.sni_406_17Canavero S., Ren X. Advancing the technology for head transplants: from immunology to peripheral nerve fusion. Surg Neurol Int 2019;10:240. DOI: 10.25259/SNI_495_2019Canavero S., Ren X. Advancing the technology for head transplants: from immunology to peripheral nerve fusion. Surg Neurol Int 2019;10:240. DOI: 10.25259/SNI_495_2019Canavero S. HEAVEN: The head anastomosis venture Project outline for the first human head transplantation with spinal linkage (GEMINI). Surg Neurol Int 2013;4(Suppl 1):S335–42. DOI: 10.4103/2152-7806.113444Canavero S. HEAVEN: The head anastomosis venture Project outline for the first human head transplantation with spinal linkage (GEMINI). Surg Neurol Int 2013;4(Suppl 1):S335–42. DOI: 10.4103/2152-7806.113444Cho Y., Borgens R.B. Polymer and nano-technology applications for repair and reconstruction of the central nervous system. Exp Neurol 2012;233(1):126–44. DOI: 10.1016/j.expneurol.2011.09.028Cho Y., Borgens R.B. Polymer and nano-technology applications for repair and reconstruction of the central nervous system. Exp Neurol 2012;233(1):126–44. DOI: 10.1016/j.expneurol.2011.09.028Gao W., Li J., Cirillo J. et al. Action at a distance: functional drug delivery using electromagnetic-field-responsive polypyrrole nanowires. Langmuir 2014;30(26):7778–88. DOI: 10.1021/la500033bGao W., Li J., Cirillo J. et al. Action at a distance: functional drug delivery using electromagnetic-field-responsive polypyrrole nanowires. Langmuir 2014;30(26):7778–88. DOI: 10.1021/la500033bKim C.Y., Sikkema W.K., Hwang I.K. et al. Spinal cord fusion with PEG-GNRs (TexasPEG): neurophysiological recovery in 24 hours in rats. Surg Neurol Int 2016;7(Suppl 24):S632–6. DOI:10.4103/2152-7806.190475Kim C.Y., Sikkema W.K., Hwang I.K. et al. Spinal cord fusion with PEG-GNRs (TexasPEG): neurophysiological recovery in 24 hours in rats. Surg Neurol Int 2016;7(Suppl 24):S632–6. DOI:10.4103/2152-7806.190475Nehrt A., Hamann K., Ouyang H., Shi R. Polyethylene glycol enhances axolemmal resealing following transection in cultured cells and in ex vivo spinal cord. J Neurotrauma 2010;27(1):151–61. DOI: 10.1089/neu.2009.0993Nehrt A., Hamann K., Ouyang H., Shi R. Polyethylene glycol enhances axolemmal resealing following transection in cultured cells and in ex vivo spinal cord. J Neurotrauma 2010;27(1):151–61. DOI: 10.1089/neu.2009.0993Bamba R., Riley D.C., Kelm N.D. et al. A novel technique using hydrophilic polymers to promote axonal fusion. Neural Regen Res 2016;11(4):525–8. DOI: 10.4103/1673-5374.180724Bamba R., Riley D.C., Kelm N.D. et al. A novel technique using hydrophilic polymers to promote axonal fusion. Neural Regen Res 2016;11(4):525–8. DOI: 10.4103/1673-5374.180724Bittner G.D., Rokkappanavar K.K., Peduzzi J.D. Application and implications of polyethylene glycol-fusion as a novel technology to repair injured spinal cords. Neural Regen Res 2015;10(9):1406–8. DOI: 10.4103/1673-5374.162772Bittner G.D., Rokkappanavar K.K., Peduzzi J.D. Application and implications of polyethylene glycol-fusion as a novel technology to repair injured spinal cords. Neural Regen Res 2015;10(9):1406–8. DOI: 10.4103/1673-5374.162772Kerschensteiner M., Schwab M., Lichtman J., Misgeld T. In vivo imaging of axonal degeneration and regeneration in the injured spinal cord. Nat Med 2005;11(5):572–7. DOI: 10.1038/nm1229Kerschensteiner M., Schwab M., Lichtman J., Misgeld T. In vivo imaging of axonal degeneration and regeneration in the injured spinal cord. Nat Med 2005;11(5):572–7. DOI: 10.1038/nm1229Ren S., Liu Z., Kim C.Y. et al. Reconstruction of the spinal cord of spinal transected dogs with polyethylene glycol. Surg Neurol Int 2019;10:50. DOI: 10.25259/SNI-73-2019Ren S., Liu Z., Kim C.Y. et al. Reconstruction of the spinal cord of spinal transected dogs with polyethylene glycol. Surg Neurol Int 2019;10:50. DOI: 10.25259/SNI-73-2019Kim C.Y. PEG-assisted reconstruction of the cervical spinal cord in rats: effects on motor conduction at 1 h. Spinal Cord 2016;54(10):910–2. DOI: 10.1038/sc.2016.72Kim C.Y. PEG-assisted reconstruction of the cervical spinal cord in rats: effects on motor conduction at 1 h. Spinal Cord 2016;54(10):910–2. DOI: 10.1038/sc.2016.72Nishio T., Fujiwara H., Kanno I. Immediate elimination of injured white matter tissue achieves a rapid axonal growth across the severed spinal cord in adult rats. Neurosci Res 2018;131:19–29. DOI: 10.1016/j.neures.2017.10.011Nishio T., Fujiwara H., Kanno I. Immediate elimination of injured white matter tissue achieves a rapid axonal growth across the severed spinal cord in adult rats. Neurosci Res 2018;131:19–29. DOI: 10.1016/j.neures.2017.10.011Yildirim F.B., Sarikcioglu L. Marie Jean Pierre Flourens (1794– 1867): an extraordinary scientist of his time. J Neurol Neurosurg Psychiatry 2007;78(8):852. DOI: 10.1136/jnnp.2007.118380Yildirim F.B., Sarikcioglu L. Marie Jean Pierre Flourens (1794– 1867): an extraordinary scientist of his time. J Neurol Neurosurg Psychiatry 2007;78(8):852. DOI: 10.1136/jnnp.2007.118380

The authors declare that there are no conflicts of interest present.