neurosurgeryНейрохирургияRussian journal of neurosurgery1683-32952587-7569Издательский дом "МедИНК"10.17650/1683-3295-2024-26-1-92-98neurosurgery-1504Research ArticleНАБЛЮДЕНИЕ ИЗ ПРАКТИКИFROM PRACTICECOVID‑19‑ассоциированный остеомиелит лобной кости. Клиническое наблюдение и обзор литературыCOVID-19-associated frontal bone osteomyelitis. Clinical case and literature reviewhttps://orcid.org/0000-0002-6715-6021ЕвзиковГ. Ю.EvzikovG. Yu.

119021 Москва, ул. Россолимо, 11, стр. 1

Bld. 1, 11 Rossolimo St., Moscow 119021

https://orcid.org/0000-0001-8839-3096НеретинД. Ю.NeretinD. Yu.

Даниил Юрьевич Неретин

119021 Москва, ул. Россолимо, 11, стр. 1

Daniil Yuryevich Neretin

Bld. 1, 11 Rossolimo St., Moscow 119021

neretin.neuro@gmail.comКафедра нервных болезней и нейрохирургии ФГАОУ ВО «Первый Московский государственный медицинский университет им. И. М. Сеченова» Минздрава России (Сеченовский университет)РоссияDepartment of Nervous Diseases and Neurosurgery, I. M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)Russian FederationКлиника нервных болезней им. А. Я. Кожевникова Университетской клинической больницы № 3 ФГАОУ ВО «Первый Московский государственный медицинский университет им. И. М. Сеченова» Минздрава России (Сеченовский университет)РоссияA.Ya. Kozhevnikov Clinic of Nervous Diseases of the University Clinical Hospital No. 3, I. M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)Russian Federation20240504202426192‑98Copyright © Евзиков Г.Ю., Неретин Д.Ю., 20242024Евзиков Г.Ю., Неретин Д.Ю.Evzikov G.Y., Neretin D.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.therjn.com/jour/article/view/1504

COVID‑19‑ассоциированный остеомиелит – гнойно‑некротическое осложнение перенесенной коронавирусной инфекции. Большинство описанных в мировой литературе случаев данного осложнения вызваны грибком Mucorales. Мукормикоз является тяжелым осложнением COVID‑19, ассоциированным с высокой летальностью. Наиболее часто поражение затрагивает придаточные пазухи носа, кости лицевого скелета и глазницы. В связи со склонностью к быстрому прогрессированию заболевания важно помнить о наличии взаимосвязи между инфекцией COVID‑19 и гнойно‑некротическим поражением костей черепа, которое может осложниться поражением мозга.

В статье представлено крайне редкое наблюдение COVID‑19‑ассоциированного остеомиелита с поражением чешуи лобной кости, осложнившегося формированием двусторонних симметричных подапоневротических абсцессов в проекции лобных бугров.

COVID‑19‑associated osteomyelitis is a purulo‑necrotic complication of past coronaviral infection. The majority of described cases of this complication are caused by Mucorales fungi. Mucormycosis is a severe complication of COVID‑19 associated with high mortality rate. Most commonly it affects maxillary sinuses, facial bones, and orbits. Due to quick progression of the disease, it is important to remember the association between COVID‑19 infection and purulo‑necrotic lesions of the skull that can be complicated by brain involvement.

The article presents a very rare observation of COVID‑19‑associated osteomyelitis affecting the squamous part of the frontal bone complicated by formation of bilateral symmetrical subgaleal abscesses in the projection of the frontal eminences.

COVID‑19‑ассоциированный остеомиелитосложнение коронавирусной инфекциимукормикозгнойно‑некротическое осложнениепоражение костей черепаабсцессCOVID‑19‑associated osteomyelitiscomplication of coronaviral infectionmucormycosispurulo‑necrotic complicationskull lesionsabscessReferencesБаранова И.Б., Яременко А.И., Зубарева А.А. и др. Мукормикоз костей лицевого черепа, полости носа и околоносовых пазух у пациентов, перенесших COVID-19. Клиническая микробиология и антимикробная химиотерапия 2021;23(4):347–58. DOI: 10.36488/cmac.2021.4.347-358Baranova I.B., Yaremenko A.I., Zubareva A.A. et al. Mucormycosis of the bones of the facial skull, nasal cavity and paranasal sinuses in patients with COVID-19. Klinicheskaya mikrobiologiya i antimikrobnaya khimioterpiya = Clinical Microbiology and Antimicrobial Chemotherapy 2021;23(4):347–58. (In Russ.). DOI: 10.36488/cmac.2021.4.347-358Hussain S., Riad A., Singh A. et al. Global prevalence of COVID-19-associated mucormycosis (CAM): living systematic review and meta-analysis. J Fungi (Basel) 2021;7(11):985. DOI: 10.3390/jof7110985Hussain S., Riad A., Singh A. et al. Global prevalence of COVID-19-associated mucormycosis (CAM): living systematic review and meta-analysis. J Fungi (Basel) 2021;7(11):985. DOI: 10.3390/jof7110985Elmokadem A.H., Bayoumi D., Mansour M. et al. COVID-19associated acute invasive fungal sinusitis: clinical and imaging findings. J Neuroimaging 2022;32(4):676–89. DOI: 10.1111/jon.12967Elmokadem A.H., Bayoumi D., Mansour M. et al. COVID-19associated acute invasive fungal sinusitis: clinical and imaging findings. J Neuroimaging 2022;32(4):676–89. DOI: 10.1111/jon.12967Muthu V., Rudramurthy S.M., Chakrabarti A., Agarwal R. Epidemiology and pathophysiology of COVID-19-associated mucormycosis: India versus the rest of the world. Mycopathologia 2021;186(6):739–54. DOI: 10.1007/s11046-021-00584-8Muthu V., Rudramurthy S.M., Chakrabarti A., Agarwal R. Epidemiology and pathophysiology of COVID-19-associated mucormycosis: India versus the rest of the world. Mycopathologia 2021;186(6):739–54. DOI: 10.1007/s11046-021-00584-8Dar-Odeh N., Bobamuratova D.T., Alnazzawi A. et al. Jaw-related complications in COVID-19 patients; a systematic review. Cranio 2022:1–8. Online ahead of print. DOI: 10.1080/08869634.2022.2031438Dar-Odeh N., Bobamuratova D.T., Alnazzawi A. et al. Jaw-related complications in COVID-19 patients; a systematic review. Cranio 2022:1–8. Online ahead of print. DOI: 10.1080/08869634.2022.2031438Nasir N., Farooqi J., Mahmood S.F., Jabeen K. COVID-19 associated mucormycosis: a life-threatening complication in patients admitted with severe to critical COVID-19 from Pakistan. Clin Microbiol Infect 2021;27(11):1704–7. DOI: 10.1016/j.cmi.2021.07.038Nasir N., Farooqi J., Mahmood S.F., Jabeen K. COVID-19 associated mucormycosis: a life-threatening complication in patients admitted with severe to critical COVID-19 from Pakistan. Clin Microbiol Infect 2021;27(11):1704–7. DOI: 10.1016/j.cmi.2021.07.038Prakash H., Chakrabarti A. Global epidemiology of mucormycosis. J Fungi (Basel) 2019;5(1):26. DOI: 10.3390/jof5010026Prakash H., Chakrabarti A. Global epidemiology of mucormycosis. J Fungi (Basel) 2019;5(1):26. DOI: 10.3390/jof5010026Rudramurthy S.M., Hoenigl M., Meis J.F. et al. ECMM/ISHAM recommendations for clinical management of COVID-19 associated mucormycosis in low-and middle-income countries. Mycoses 2021;64(9):1028–37. DOI: 10.1111/myc.13335Rudramurthy S.M., Hoenigl M., Meis J.F. et al. ECMM/ISHAM recommendations for clinical management of COVID-19 associated mucormycosis in low-and middle-income countries. Mycoses 2021;64(9):1028–37. DOI: 10.1111/myc.13335Selarka L., Sharma S., Saini D. et al. Mucormycosis and COVID-19: an epidemic within a pandemic in India. Mycoses 2021;64(10):1253–60. DOI: 10.1111/myc.13353Selarka L., Sharma S., Saini D. et al. Mucormycosis and COVID-19: an epidemic within a pandemic in India. Mycoses 2021;64(10):1253–60. DOI: 10.1111/myc.13353Song G., Liang G., Liu W. Fungal co-infections associated with global COVID-19 pandemic: a clinical and diagnostic perspective from China. Mycopathologia 2020;185(4):599–606. DOI: 10.1007/s11046-020-00462-9Song G., Liang G., Liu W. Fungal co-infections associated with global COVID-19 pandemic: a clinical and diagnostic perspective from China. Mycopathologia 2020;185(4):599–606. DOI: 10.1007/s11046-020-00462-9Амонов Ш., Каршиев Х., Эназаров Д., Нормуминов Ф. Лечебная тактика у больных с постковидными гнойно-воспалительными осложнениями челюстно-лицевой области. Стоматология 2021;82(1):92–5. DOI: 10.34920/2091-5845-2021-30Amonov Sh., Karshiev Kh., Enazarov D., Normuminov F. Therapeutic tactics in patients with post-COVID purulentinflammatory complications of the maxillofacial region. Stomatologiya = Dentistry 2021;82(1):92–5. (In Russ.). DOI: 10.34920/2091-5845-2021-30Убайдуллаев М.Б., Сулейманов А.М., Агайдарова Г.М. Постковидный синдром. Случаи из практики. Хронический остеомиелит верхней челюсти. Медицина и инновации 2021;1(4):333–6.Ubaidullaev M.B., Suleymanov A.M., Agaidarova G.M. PostCOVID syndrome. Cases from practice. Chronic osteomyelitis of the upper jaw. Meditsina i innovatsii = Medicine and Innovation 2021;1(4):333–6. (In Russ.).Bobamuratova D.T., Boymuradov Sh.A., Dar-Odeh N.S. et al. Impact of COVID-19 disease and its treatment on the development of maxillofacial complications. Adv Oral Maxillofac Surg 2021;4(10):100169. DOI: 10.1016/j.adoms.2021.100169Bobamuratova D.T., Boymuradov Sh.A., Dar-Odeh N.S. et al. Impact of COVID-19 disease and its treatment on the development of maxillofacial complications. Adv Oral Maxillofac Surg 2021;4(10):100169. DOI: 10.1016/j.adoms.2021.100169El-Kholy N.A., El-Fattah A.M.A., Khafagy Y.W. Invasive fungal sinusitis in post COVID-19 patients: a new clinical entity. Laryngoscope 2021;131(12):2652–8. DOI: 10.1002/lary.29632El-Kholy N.A., El-Fattah A.M.A., Khafagy Y.W. Invasive fungal sinusitis in post COVID-19 patients: a new clinical entity. Laryngoscope 2021;131(12):2652–8. DOI: 10.1002/lary.29632Singh A.K., Singh R., Joshi S.R., Misra A. Mucormycosis in COVID-19: a systematic review of cases reported worldwide and in India. Diabetes Metab Syndr 2021;15(4):102146. DOI: 10.1016/j.dsx.2021.05.019Singh A.K., Singh R., Joshi S.R., Misra A. Mucormycosis in COVID-19: a systematic review of cases reported worldwide and in India. Diabetes Metab Syndr 2021;15(4):102146. DOI: 10.1016/j.dsx.2021.05.019Jindal G., Sethi A., Bhargarva K. et al. Imaging findings in invasive rhino-orbito-cerebral mucormycosis in post-COVID-19 patients. Proc (Bayl Univ Med Cent) 2021;35(1):32–4. DOI: 10.1080/08998280.2021.1981100Jindal G., Sethi A., Bhargarva K. et al. Imaging findings in invasive rhino-orbito-cerebral mucormycosis in post-COVID-19 patients. Proc (Bayl Univ Med Cent) 2021;35(1):32–4. DOI: 10.1080/08998280.2021.1981100Kondapavuluri S.K., Anchala V.K.R., Bandlapalli S. et al. Spectrum of MR imaging findings of sinonasalmucormycosis in post COVID-19 patients. Br J Radiol 2021;94(1127):20210648. DOI: 10.1259/bjr.20210648Kondapavuluri S.K., Anchala V.K.R., Bandlapalli S. et al. Spectrum of MR imaging findings of sinonasalmucormycosis in post COVID-19 patients. Br J Radiol 2021;94(1127):20210648. DOI: 10.1259/bjr.20210648Hoenigl M., Seidel D., Carvalho A. et al. The emergence of COVID-19 associated mucormycosis: a review of cases from 18 countries. Lancet Microbe 2022;3(7):e543–e52. DOI: 10.1016/S2666-5247(21)00237-8Hoenigl M., Seidel D., Carvalho A. et al. The emergence of COVID-19 associated mucormycosis: a review of cases from 18 countries. Lancet Microbe 2022;3(7):e543–e52. DOI: 10.1016/S2666-5247(21)00237-8Eswaran S., Balan S.K., Saravanam P.K. Acute fulminant mucormycosis triggered by Covid 19 infection in a young patient. Indian J Otolaryngol Head Neck Surg 2022;74(Suppl 2):3442–6. DOI: 10.1007/s12070-021-02689-4Eswaran S., Balan S.K., Saravanam P.K. Acute fulminant mucormycosis triggered by Covid 19 infection in a young patient. Indian J Otolaryngol Head Neck Surg 2022;74(Suppl 2):3442–6. DOI: 10.1007/s12070-021-02689-4

The authors declare that there are no conflicts of interest present.