neurosurgeryНейрохирургияRussian journal of neurosurgery1683-32952587-7569Издательский дом "МедИНК"10.17650/1683-3295-2023-25-3-69-77neurosurgery-1412Research ArticleОРИГИНАЛЬНАЯ РАБОТАORIGINAL REPORTОпухоли периферических нервов у взрослых и детей: клинико‑диагностические характеристикиPeripheral nerve tumors in adults and children: clinical and diagnostic characteristicshttps://orcid.org/0000-0002-6244-0867ДружининД. С.DruzhininD. S.

Дмитрий Сергеевич Дружинин

Кафедра нервных болезней с медицинской генетикой и нейрохирургией

150006 Ярославль, ул. Революционная, 6

Dmitry Sergeevich Druzhinin 

The Department of Nervous Diseases with Medical Genetics and Neurosurgery

6 Revolutsionnaya St., Yaroslavl 150006

druzhininds@gmail.comКарапетянА. С.KarapetyanA. S.

115446 Москва, Коломенский проезд, 4

4 Kolomenskiy proezd, Moscow 115446

НовиковМ. Л.NovikovM. L.

150033 Ярославль, Тутаевское шоссе, 93

93 Tutaevskoe Shosse, Yaroslavl 150033

https://orcid.org/0000-0001-7853-0210ДружининаЕ. С.DruzhininaE. S.

117997 Москва, ул. Островитянова, 1

1 Ostrovityanova St., Moscow 117997

ФГБОУ ВО «Ярославский государственный медицинский университет» Минздрава РоссииРоссияYaroslavl State Medical University, Ministry of Health of RussiaRussian FederationГБУЗ г. Москвы «Городская клиническая больница им. С.С. Юдина Департамента здравоохранения города Москвы»РоссияS.S. Yudin City Clinical Hospital, Moscow Healthcare DepartmentRussian FederationМедицинский центр «Мотус»РоссияMedical center “Motus”Russian FederationФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава РоссииРоссияN.I. Pirogov Russian National Research Medical University, Ministry of Health of RussiaRussian Federation2023181020232536977Copyright © Дружинин Д.С., Карапетян А.С., Новиков М.Л., Дружинина Е.С., 20232023Дружинин Д.С., Карапетян А.С., Новиков М.Л., Дружинина Е.С.Druzhinin D.S., Karapetyan A.S., Novikov M.L., Druzhinina E.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.therjn.com/jour/article/view/1412Введение

Введение. Диагностика новообразований периферических нервов представляет собой сложную задачу, особенно в случаях с множественным распределением в периферической нервной системе.

Цель исследования – описать клинико‑инструментальные характеристики пациентов с первичными одиночными и множественными новообразованиями периферических нервов.

Материалы и методы

Материалы и методы. Проанализированы данные 45 пациентов. По результатам проведенного обследования пациенты ретроспективно были распределены в 2 группы: 1) с одиночными новообразованиями: шванномами (n = 22), нейрофибромами (n = 10), периневриномами (n = 5), нейрофибросаркомами (n = 2); 2) с множественными новообразованиями: шванноматоз (n = 3) и нейрофиброматоз (n = 3).

Результаты

Результаты. В ходе исследования не обнаружено различий в выраженности моторного дефицита и результатах нейрофизиологических исследований между одиночными и множественными опухолями, однако выявлены различия среди отдельных патоморфологических типов. Наиболее доброкачественное течение наблюдалось у пациентов с шванномами, в том числе и множественными; тяжелый моторный дефицит отмечен у пациентов с нейрофибросаркомами и перекрестными нейрофибромами. Болевой компонент был характерен для пациентов с нейрофибросаркомами, нейрофибромами и меланотической шванномой; периневриномы характеризовались безболевым течением.

Заключение

Заключение. Применение обязательного сканирования нервов на протяжении позволяет обнаружить образования в клинически интактных участках, а также в других нервах.

Aim

Aim. To describe clinical and instrumental characteristics of patients with primary solitary and multiple tumors of the peripheral nerves.

Materials and methods

Materials and methods. Data from 45 patients were analyzed. In accordance with the examination results, the patients were retrospectively divided into 2 groups: 1) with solitary tumors: schwannomas (n = 22), neurofibromas (n = 10), perineuriomas (n = 5), neurofibrosarcomas (n = 2); 2) with multiple tumors: schwannomatosis (n = 3) and neurofibromatosis (n = 3).

Results

Results. The study did not show differences in the severity of motor deficit and the results of neurophysiological exams between solitary and multiple tumors; however, differences between pathomorphological types were observed. The most benign disease course was observed in patients with schwannomas, including multiple schwannomas; severe motor deficit was observed in patients with neurofibrosarcomas and crossover neurofibromas. Pain component was characteristic of neurofibrosarcomas, neurofibromas and melanotic schwannoma; perineuriomas were characterized by painless progression.

Conclusion

Conclusion. Compulsory scan along the nerve allows to find tumors in clinically intact areas and other nerves.

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The authors declare that there are no conflicts of interest present.