neurosurgeryНейрохирургияRussian journal of neurosurgery1683-32952587-7569Издательский дом "МедИНК"neurosurgery-116Research ArticleОБЗОРЫ ЛИТЕРАТУРЫLITERATURE REVIEWЭКСПЕРИМЕНТАЛЬНЫЕ МОДЕЛИ ИЗУЧЕНИЯ СОСУДИСТОГО СПАЗМА ПРИ НЕТРАВМАТИЧЕСКОМ СУБАРАХНОИДАЛЬНОМ КРОВОИЗЛИЯНИИ IN VIVOThe experimental models for examination of angiospasm because of non-traumatic subarachnoid hemorrhage in vivoПриродовАлександр ВладиславовичPrirodovA. V.aprirodov@yandex.ruБахаревЕвгений ЮрьевичBakharevE. Yu.ads_nvkz@mail.ruНИИ скорой помощи им. Н.В. СклифосовскогоRussian Federation201405102017036570Copyright © Природов А.В., Бахарев Е.Ю., 20172017Природов А.В., Бахарев Е.Ю.Prirodov A.V., Bakharev E.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.therjn.com/jour/article/view/116

Проведен анализ данных литературы по моделированию сосудистого спазма при нетравматических субарахноидальных кровоизлияниях на различных лабораторных животных (обезьяны, собаки, крысы). Обсуждены основные методики моделирования спазма, особенности его оценки в эксперименте, сопоставимость результатов экспериментальных данных с клиническими. Рассмотрена потенциальная возможность изучения различных способов профилактики и лечения сосудистого спазма на конкретных биологических моделях. Отдельное внимание уделено особенностям моделирования спазма у «небольших» лабораторных животных, в частности крыс.

The main problems of cerebral angiopasm (CA) modeling because of non-traumatic subarachnoid hemorrhage at various biological animals (primates, dogs, rats) are presented. The main methods of CA modeling as well as features of its assessment in experiment and compatibility of experimental and clinical data are discussed. The potential opportunity for examination of various prophylaxis methods and CA treatment on certain biological models are considered. The special attention is paid for features of CA at «small» laboratory animals, rats in particular.

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