References

neurosurgery

Нейрохирургия

Russian journal of neurosurgery

1683-32952587-7569

Издательский дом "МедИНК"

neurosurgery-100

Research Article

ОБЗОРЫ ЛИТЕРАТУРЫ

LITERATURE REVIEW

Биохимические маркеры черепно-мозговой травмы

Biochemical markers of head injury

Сосновский

Евгений Александрович

Sosnovsky

E. A.

noemail@neicon.ru

Пурас

Юлия Владимировна

Puras

Ju. V.

noemail@neicon.ru

Талыпов

Александр Эрнестович

Talypov

A. E.

dr.talypov@mail.ru

Московский государственный медико-стоматологический университет им. А.И. ЕвдокимоваRussian FederationНИИ скорой помощи им. Н.В. СклифосовскогоRussian Federation

2014

05102017

028391

2017

Сосновский Е.А., Пурас Ю.В., Талыпов А.Э.

Sosnovsky E.A., Puras J.V., Talypov A.E.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.therjn.com/jour/article/view/100

Представлен обзор литературы, посвященный современным биохимическим маркерам, применяемым при диагностике, оценке эффективности лечения и прогнозе исходов у пострадавших с черепномозговой травмой (ЧМТ). Изложены основные требования, предъявляемые на сегодняшний день к современным биохимическим маркерам. Подробно описаны преимущества, недостатки и область применения наиболее изученных и используемых в клинической практике биохимических маркеров ЧМТ: протеина S-100β, нейрон-специфической енолазы, глиального фибриллярного кислого протеина, протеина С-tau, продуктов распада спектрина и маркеров апоптоза (каспазы-3, протеина Fas и белков bcl-2).

This literature review is dedicated to biochemical markers nowadays used for diagnostics as well as for estimation of treatment effectiveness and outcomes prognosis at patients with head injury (HI). The main current requirements for biochemical markers are presented. The advantages, disadvantages and application field of the most examined and clinically used biochemical markers of HI (S-100β protein, neuron-specific enolase, glial fibrillary acid protein, С-tau protein, degradation products of spectrin and markers for apaptosis - caspase-3, Fas protein and bcl-2 proteins) are described in details.

черепно-мозговая травмабиохимические маркеры повреждения мозгаhead injurybiochemical markers of brain damage

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The authors declare that there are no conflicts of interest present.